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THC-O Is To Cannabis What Heroin Is To Opium — Is It Legal?

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Like heroin, THC-O is several times more potent than THC and the risks associated with it are by no means moderate.

THC-O acetate (THC-O, ATHC) is becoming a popular option among cannabis consumers. According to Google trends, interest in this compound peaked around mid-2021.

Consumers are turning to THC-O for two likely reasons. The first is that delta-8 THC acetate is hemp-derived and therefore legal and accessible in states where marijuana is illegal.

The more exciting reason is that THC-O is supposedly a psychedelic cannabinoid. In other words, you will be taking a trip on cannabis and achieving the highest spiritual experiences and probably even ego death. Some sources claim that THC-O acetate is up to 300 times more potent than THC. More realistic sources claim that THC-O acetate is up to three times more potent, but we are not sure.

But for recreational users craving that “elusive high,” this sounds unimaginable. Is that not the same reason why the naturally occurring opium was ditched on the streets in preference for heroin?

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Photo by MART PRODUCTION via Pexels

Opium Versus Heroin

Opium, like cannabis, is a naturally occurring compound that’s derived from the poppy plant. Heroin on the other hand is a semi-synthetic compound that’s made from morphine, which comes from the poppy plant. Because heroin is an enhanced form of opium, the effects are stronger.

Heroin was originally created to be a medical analgesic. However, it was soon discovered that it triggered several adverse effects including dependence, addiction, and overdose-related deaths. Its clinical use was hence stopped but the drug found its way to the illicit market where its use is still rampant. Like marijuana, heroin is classified by the DEA under Schedule I compounds that according to the DEA have no known medical use and a high potential for abuse.

THC-O Acetate Is a Synthetic Cannabinoid

THC-O like heroin is a synthetic cannabinoid that is made through the acetylation of THC (could be D8, D9, or D10) in the lab. Because it’s not a natural product don’t expect to find it in shops that sell natural cannabis products.

How Is THC-O Made?

THC is heated and mixed with acetic anhydride in a lab setting. A chemical reaction occurs that converts the THC to THC-O. This chemical reaction is dangerous and hence should only be carried out by a qualified chemist and only in the right setting.

THC-O Acetate Is a Pro Drug

A prodrug can be defined as any drug that is biologically inactive when ingested but once metabolized it releases a biologically active compound. THC-O acts in this way.

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Photo by Esther Kelleter / EyeEm/Getty Images

When acetic acid is added to THC it forms a barrier that prevents the breakdown of the THC by enzymes until it gets to the liver where it is deacetylatedated and releases the biologically active THC. Like other pro-drugs, the effects of THC-O take a longer time to kick in (lag time) because of the extra step involved in “activating” the drug. This can be anywhere around 30 minutes for inhaled THC-O or up to 1.5 hours for ingested THC-O.

Is THC-O a Psychedelic?
It is believed that THC-O provides THC that has higher bioavailability. This also means that the body has higher circulating levels of THC and 11-Hydroxy-THC. Though the effects take a longer time to kick in, once they do they are likely to come crashing in and it will be a long while before the effects subside. Higher levels of circulating 11-hydroxy-THC might be responsible for the psychedelic effects that have been reported after the consumption of THC-O.

Is THC-O Legal?
Most of the THC-O Acetate that’s being sold online and in smoke shops is actually the acetate of delta-8-THC and not delta-9-THC. Delta 8 is usually made from hemp-derived CBD and consequently, it can be argued that THC-O made in this way is also legal. However, it should be noted that THC-O is a synthetic cannabinoid. Here’s what the law says about synthetic THC.

“For synthetically derived tetrahydrocannabinols, the concentration of D9 -THC is not a determining factor in whether the material is a controlled substance. All synthetically derived tetrahydrocannabinols remain Schedule I controlled substances.”

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Photo by boonchai wedmakawand/Getty Images

THC-O, Ketene Formation, and EVALI

Most THC-O products in the market currently are in the form of vapes. The process of vaping THC-O is likely to produce harmful byproducts such as ketenes. Ketenes are highly reactive and will easily form acetic acid when they react with water in the nasal and oral mucosa.

A study by the Portland State University (PSU) found a link between vaping cannabinoid acetates with the production of the toxic gas Ketene. An earlier study linked ketene production with EVALI as the causative agent.

Safety of THC-O: Dr. Ethan Russo Opines

Dr. Ethan Russo is a notable medical cannabis thought leader and founder and CEO of a medical cannabis research company CReDO science. In an interview with Hemp Grower, Dr. Russo expressed reservations with the safety of THC-O. In his opinion, we don’t need a compound that is three times more potent (putatively) than THC. Known side effects of THC include extreme paranoia and anxiety that may land you in the ER. Vasovagal syncope, which may cause sudden falls and fractures, is also a possibility. THC-O may amplify these adverse effects or trigger off-target effects that we’re not aware of. In his words, as far as THC-O goes, “don’t go there.”

Synthetic Cannabinoids Are a Sham!

Like heroin, THC-O is several times more potent than THC and the risks associated with it are by no means moderate. In addition, there’s the risk of ketene formation when THC-O is vaped. Ketene has been linked to serious and sometimes even fatal lung injuries.

Are synthetics worth the risk?

Maybe not.

As Dr. Russo opines, synthetic cannabinoids and the risks they present are a “byproduct of cannabis prohibition.” And as he goes further to state, they should probably be avoided at all costs.

Source: https://thefreshtoast.com/cannabis/thc-o-is-to-cannabis-what-heroin-is-to-opium-is-it-legal/

Business

Alleged Crores Pharma Scam Mastermind Arrested from Surat

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After evading law enforcement for nearly 13 years, an accused linked to a large-scale pharmaceutical fraud case has been arrested by Delhi Police from Surat, Gujarat. The suspect is alleged to have orchestrated a series of financial scams involving fake identities, forged documents, and dishonoured cheques used to procure high-value pharmaceutical raw materials.

Authorities say the accused, identified as Himmat Singh Lodha, is believed to have defrauded multiple pharmaceutical companies in Delhi of goods worth approximately ₹98 lakh before disappearing and remaining underground for years.

Fake Business Deals and Dishonoured Cheques Used in Fraud

Investigators claim the accused posed as a legitimate pharmaceutical trader and placed bulk orders for expensive drug ingredients, offering post-dated cheques as payment security.

In one documented case from 2013, he allegedly obtained around 550 kilograms of Gliclazide, a diabetes-related pharmaceutical ingredient, valued at over ₹26 lakh. When suppliers attempted to encash the cheques, they were reportedly returned with the remark “account closed.”

Following the transaction, the accused allegedly vacated his office and rented residence and disappeared without settling payments. He was later declared a proclaimed offender in 2016 after repeatedly failing to appear before court proceedings. Authorities had also issued a reward for information leading to his arrest.

Multiple Identities and Repeated Fraud Pattern

Police investigations further link the accused to another cheating case dating back to 2012, where he allegedly used a fake identity, “Kailash Jain,” to obtain a large consignment of Ambroxol HCL, a pharmaceutical compound used in cough medications. The value of that consignment was estimated at around ₹72 lakh.

Officials believe the accused followed a consistent modus operandi—posing as a credible businessman, securing high-value goods on deferred payment terms, and then disappearing after delivery while shutting down business operations.

Investigators suspect that forged business records, fake company credentials, and fabricated financial histories were used to build trust with suppliers and gain access to expensive raw materials.

Multi-State Surveillance Leads to Arrest in Surat

A special Crime Branch team tracked the accused through coordinated surveillance efforts across multiple cities, including Mumbai, Ahmedabad, and Surat. After nearly a month of technical monitoring and intelligence gathering, officials located and arrested him from a residential area in Surat.

Authorities also revealed that the accused had been involved in property-related activities while staying under the radar to avoid detection.

Growing Threat of Corporate Identity Fraud

The case highlights a rising trend of organised financial fraud targeting industries that rely heavily on trust-based transactions and deferred payments. Experts note that criminals increasingly exploit gaps in corporate verification systems by using fake GST registrations, temporary offices, and forged documentation to appear legitimate.

Cybercrime and financial fraud specialists warn that such schemes are becoming more complex with the widespread availability of digital business tools, making it easier to create convincing but fraudulent corporate identities.

Experts Urge Stronger Due Diligence in High-Value Transactions

Experts, including former IPS officer and cybercrime specialist Prof. Triveni Singh, emphasize the need for stricter verification procedures in commercial dealings. He noted that relying solely on paperwork or digital business profiles can expose companies to significant financial risk.

Authorities and industry experts recommend physical verification of business operations, bank account validation, and detailed background checks before engaging in high-value or deferred-payment transactions—particularly in sectors like pharmaceuticals, where single consignments can involve transactions worth crores.

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EU Pressure Builds on Google as Regulators Face Calls for Massive Fine Over Search Practices

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A growing coalition of European industry groups is intensifying pressure on regulators to take decisive action against Google over allegations of unfair search practices that could reshape competition rules across the region’s digital economy.

Investigation Under Digital Markets Act Gains Momentum

The case is being examined by the European Commission under the European Union’s landmark Digital Markets Act (DMA), introduced to curb the dominance of major technology platforms and ensure fair competition.

Launched in March 2024, the investigation focuses on whether Google has been prioritising its own services in search results, potentially disadvantaging rival businesses that rely on online visibility to reach customers.

Industry Groups Demand Swift Action

Several prominent European organizations have jointly urged regulators to conclude the probe without further delay. They argue that prolonged investigations allow alleged anti-competitive practices to continue, putting European companies—especially startups—at a disadvantage.

Signatories include the European Publishers Council, the European Magazine Media Association, the European Tech Alliance, and EU Travel Tech.

In a joint statement, these groups warned that delays in enforcement are affecting innovation, profitability, and growth prospects for regional businesses competing in digital markets.

Google Denies Allegations

Google has rejected claims of bias, stating that its search algorithms are designed to deliver the most relevant and useful results to users. The company has also proposed adjustments to address regulatory concerns.

However, critics argue that these changes are insufficient and fail to address the core issue of market dominance.

Potential Billion-Euro Penalties

If found in violation of the DMA, Google could face significant financial penalties. Under EU rules, fines can reach a substantial percentage of a company’s global turnover, potentially amounting to billions of euros.

Regulators may also impose corrective measures requiring changes to business practices, which could have long-term implications for how digital platforms operate in Europe.

Wider Implications for Big Tech

The case highlights ongoing tensions between European regulators and major U.S. technology firms. In recent years, the EU has taken a more aggressive stance in enforcing competition laws, aiming to create a level playing field for local businesses.

A final ruling against Google could set a major precedent, influencing future enforcement actions and shaping the regulatory landscape for global tech companies operating within Europe.

As scrutiny intensifies, the outcome of the investigation is expected to play a critical role in defining the future of digital competition across the European Union.

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Amazon Faces Potential Criminal Trial in Italy Over €1.2 Billion Tax Evasion Allegations

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Milan: U.S. tech giant Amazon is facing the prospect of a major legal showdown in Italy, after prosecutors in Milan formally requested a court to move forward with criminal proceedings over alleged tax evasion totaling approximately ₹12,500 crore (€1.2 billion).

The case targets Amazon’s European division along with four senior executives, marking one of the most significant tax-related investigations involving a global e-commerce platform in Europe.

Trial Push Despite Multi-Million Euro Settlement

The move comes even after Amazon reached a financial settlement with Italian tax authorities in December, agreeing to pay around ₹5,500 crore (€527 million), including interest, to resolve part of the dispute.

Typically, such settlements lead to the closure of criminal investigations. However, Milan prosecutors have opted to proceed, signaling a tougher stance on alleged corporate tax violations.

A preliminary hearing is expected in the coming months, where a judge will decide whether to formally indict the company and its executives or dismiss the case.

Allegations of VAT Evasion Through Marketplace Sellers

At the center of the investigation are claims that Amazon’s platform enabled non-European Union sellers to avoid paying value-added tax (VAT) on goods sold to Italian consumers between 2019 and 2021.

Prosecutors allege that the company’s marketplace structure allowed thousands of foreign vendors—many reportedly based in China—to operate without fully disclosing their identities or tax obligations. This, authorities argue, led to substantial VAT losses for the Italian government.

Under Italian law, online platforms facilitating sales can be held partially liable if third-party sellers fail to comply with tax requirements, a key point in the prosecution’s case.

Italian Government Named as Affected Party

In their filing, prosecutors identified Italy’s Economy Ministry as the injured party, citing significant financial damage resulting from the alleged tax evasion.

Legal experts say the outcome of the case could have wide-ranging implications across the European Union, where VAT systems are harmonized and similar compliance rules apply to digital marketplaces.

Multiple Investigations Add to Pressure

The VAT probe is just one of several legal challenges facing Amazon in Italy. The European Public Prosecutor’s Office is reportedly examining additional tax-related issues covering more recent years.

Meanwhile, Milan authorities are pursuing separate investigations into alleged customs fraud linked to imports from China and whether Amazon maintained an undeclared “permanent establishment” in Italy—potentially exposing it to higher tax liabilities.

In a separate regulatory action, Italy’s data protection authority recently ordered an Amazon unit to stop using personal data from over 1,800 employees at a warehouse near Rome.

Amazon Denies Allegations

Amazon has consistently denied wrongdoing and indicated it will strongly contest the allegations in court if the case proceeds. The company has also warned that prolonged legal uncertainty could impact investor confidence and Italy’s appeal as a destination for international business.

Broader Impact on Europe’s Digital Economy

If the case moves to trial, it could become a landmark moment for the regulation of global e-commerce platforms in Europe. Governments across the region are increasingly scrutinizing how digital marketplaces handle tax compliance, especially in cross-border transactions.

With online retail continuing to expand, regulators are under mounting pressure to ensure that multinational platforms and third-party sellers adhere to the same tax rules as traditional businesses.

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