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Minor cannabinoids making major inroads targeting specific medical conditions

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New information and research about minor cannabinoids – among the 100-200 that have been identified – is helping treat different health and wellness conditions and allowing cannabis companies to sell a wider variety of products.

The products go beyond the typical THC and CBD offerings currently on store shelves, and they incorporate lesser cannabinoids such as CBN and THCV.

The new products – including edibles and vapes – allow cannabis companies to appeal to consumers seeking ways to address conditions such as obesity, sleeplessness and nausea.

“We’re better trying to understand which plants elicit what effects and how to consistently provide that to consumers so we can get away from all the meaningless strain names and get right to the point of how do you want this plant to help you feel,” said Mike Hennesy, vice president of innovation at Colorado-based edibles maker Wana Brands.

“How is this plant going to enhance your life based off of your needs?”

At the same time, researchers are studying the cannabis plant to determine whether minor cannabinoids can be effective at treating everything from epilepsy and traumatic brain injury to other conditions that have yet to be identified.

Most of the new marijuana products being developed today involve four minor cannabinoids, none of which have the same psychotropic effect as THC:

  • Cannabigerol (CBG), reputed to help fight inflammation, pain and nausea.
  • Cannabichromene(CBC), one of the most abundant cannabinoids in the plant – first isolated in 1966 – and said to play a role in anti-cancer and anti-tumor capabilities.
  • Cannabinol (CBN), reputed to be a sleep aid or sedative.
  • Tetrahydrocannabivarin (THCV), dubbed “diet weed” and purported to help with weight loss.

The appetite for these cannabinoids is growing.

Grand View Research calculates the U.S. market for minor cannabinoids totaled $4.9 billion in 2020.

The San Francisco-based market research and consulting firm projects the market will expand at a compound annual growth rate of 20.1% from 2021 to 2028.

The firm points to “the rising trend of adopting cannabinoid-based medicines over traditional medicines, owing to their affirmative health benefits for many health conditions such as chronic pain, cancer, arthritis, neurological disorders, and metabolic disorders.”

Cannabis companies offer new products

Cannabis producers and manufacturers in Canada and the United States are rolling out products incorporating minor cannabinoids.

In December, Canadian licensed producer Cronos Group announced a new gummy featuring a 3-1 ratio of CBC to THC, called Day Trip.

The Toronto-based company has two other gummies made with minor cannabinoids: Chill Bliss, with CBG, and launched in October 2021; and Deep Dreamz, with CBN.

In addition, Cronos has three different vape products based on those various gummy combinations.

Wana Brands recently released its Passionfruit Pineapple edible with a 1-to-1-to-1 CBG/CBD/THC ratio. That release follows last November’s debut of its Stay Asleep gummy, with a formulation of CBD, CBN, CBG and THC plus 30 specialized terpenes.

“So, instead of just a THC product alone with this formulation, you’re getting a multitude of benefits,” Hennesy said.

“And the reason this is important is that each cannabinoid has its own molecular shape and its own affinity for different receptors. So, if I have THC and CBG, those two molecules have some convergent and some different cannabinoid receptor targets.

“The pairing of these in the right ratios can lead to better effects than THC alone.”

Additional research

 Much research is still needed to understand the precise chemical properties of the minor cannabinoids and how they work in the human body.

Israeli cannabis scientist Raphael Mechoulam, who died earlier this month, and his team at the Hebrew University of Jerusalem have identified some of the other minor, or lesser, cannabinoids in the plant.

But it’s a difficult process.

“I never tried to count all of those,” said Oded Shoseyov, professor of plant sciences and genetics in agriculture at Hebrew University and a member of Mechoulam’s team.

“It’s actually anywhere between 100 and 200 that have been identified. And the reason I’m saying that is because there are also many synthetic cannabinoids with some chemical modifications that are still cannabinoids, maybe not natural, but they have or may have different pharmacological effects.”

Another thing researchers don’t know is if the cannabinoid profile is due to genes or to the environment, according to Daniela Vergara, an emerging crop specialist at Cornell University who founded the Agricultural Genomics Foundation.

“But if a lot of it is due to environmental effects, and has not been quantified, you need to make sure that you’re growing your strain in the right conditions for producing the compound that you want to produce.”

Israeli researchers reported that there might be certain minor cannabinoids that can treat epilepsyobesitypain and traumatic brain injury.

“I think that the pharmacological picture is still very complex,” said Shoseyov, who is working on remote sensing and machine learning of cannabis chemical composition and genetic markers.

Shoseyov was also part of the team that first isolated the THC molecule in 1964.

“Many scientists in the world are trying to isolate new cannabinoids and try to see if they work together with others that will have a certain biological effect,” he said. “But this is very tedious work.”

The role of plant genomics

Plant genomics used to develop new cannabinoids is behind the work of a number of researchers, including Colorado-based Front Range Biosciences; Montreal-based Hyasynth Bio, which is using yeast to produce cannabinoids; and both the University of California, Davis, with its Cannabis and Hemp Research Center, launched in 2019; and the Center for Research and Education Addressing Cannabis and Health at the University of Colorado Boulder.

“A lot of those minor cannabinoids are made in such tiny quantities, and we have some ideas of some of the effects that they have,” said Charles Pick, senior vice president for science and innovation at Aurora Cannabis, an Edmonton, Alberta-based licensed producer.

“But there’s the vast majority we really don’t know. So that’s sort of a tantalizing question: Is there one of those compounds available that has some sort of blockbuster impact in terms of therapeutics. We just don’t know.”

Jason MacDonald, director of cultivation operations at Native Roots, a Denver-based retail operator and grower, said he also is interested in learning more about the minor cannabinoids.

“But there’s not a ton of data behind them. And many labs have just started testing for several of these lesser cannabinoids,” he said.

“So where we’re at right now is in the beginning stages of identifying what strains contain some of these lesser-known cannabinoids and some of these rare cannabinoids, and then it’s finding out what interest there is in the market.”

Pick said Aurora is studying minor cannabinoids and company researchers are working with a cultivar that’s “sort of in an experimental stage” and has a higher-than-average level of THCV.

“With the plant, like most things in nature, you get this wonderful sort of genetic variation usually driven by mutations that have happened in the plant, so that you know the dominant cannabinoid pathway,” he said.

“But if you get mutations in some of the enzymes in that dominant cannabinoid pathway, what ends up happening is you get higher levels of sort of side products X or, in the case of CBG, which is kind of a precursor to CBD and THC, you get a buildup of that.

“When we find those sort of rare occurrences, we can essentially start to breed them and look for cultivars that have higher levels of minor cannabinoids,” Pick added.

Zac Hildenbrand, chemistry research professor at the University of Texas at El Paso, said he is trying to unearth this new understanding of what molecules are needed for specific conditions.

“So that yourself or myself could say, ‘Hey, I have condition A, and according to this literature, I need a little bit of CBD. I need some CBC, and I need these three terpenes. Show me a strain that has those components and I’ll buy that.’ Otherwise, you’re really shooting in the dark,” he said.

“People need to be making more data-driven decisions,” Hildenbrand added.

“If we’re making better, more data-driven decisions about this, then patients are going to have more favorable outcomes and then they’ll come back to cannabinoid medicine as opposed to using traditional pharmaceutical agents.”

According to Hennesy, Wana works with its suppliers and partners to establish terpene maps and then tries to match those to user outcomes and experiences.

“So it’s not only an understanding of the cannabinoid and terpene profile,” he said.

“But when you query people on how it made them feel, we can start to map these strains clustered together to produce these types of effects.

“There’s still a long way to go on that. But that’s the future for innovative companies to be working with.”

Source: https://mjbizdaily.com/minor-cannabinoids-making-major-inroads-for-specific-medical-conditions/

Business

EU Pressure Builds on Google as Regulators Face Calls for Massive Fine Over Search Practices

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A growing coalition of European industry groups is intensifying pressure on regulators to take decisive action against Google over allegations of unfair search practices that could reshape competition rules across the region’s digital economy.

Investigation Under Digital Markets Act Gains Momentum

The case is being examined by the European Commission under the European Union’s landmark Digital Markets Act (DMA), introduced to curb the dominance of major technology platforms and ensure fair competition.

Launched in March 2024, the investigation focuses on whether Google has been prioritising its own services in search results, potentially disadvantaging rival businesses that rely on online visibility to reach customers.

Industry Groups Demand Swift Action

Several prominent European organizations have jointly urged regulators to conclude the probe without further delay. They argue that prolonged investigations allow alleged anti-competitive practices to continue, putting European companies—especially startups—at a disadvantage.

Signatories include the European Publishers Council, the European Magazine Media Association, the European Tech Alliance, and EU Travel Tech.

In a joint statement, these groups warned that delays in enforcement are affecting innovation, profitability, and growth prospects for regional businesses competing in digital markets.

Google Denies Allegations

Google has rejected claims of bias, stating that its search algorithms are designed to deliver the most relevant and useful results to users. The company has also proposed adjustments to address regulatory concerns.

However, critics argue that these changes are insufficient and fail to address the core issue of market dominance.

Potential Billion-Euro Penalties

If found in violation of the DMA, Google could face significant financial penalties. Under EU rules, fines can reach a substantial percentage of a company’s global turnover, potentially amounting to billions of euros.

Regulators may also impose corrective measures requiring changes to business practices, which could have long-term implications for how digital platforms operate in Europe.

Wider Implications for Big Tech

The case highlights ongoing tensions between European regulators and major U.S. technology firms. In recent years, the EU has taken a more aggressive stance in enforcing competition laws, aiming to create a level playing field for local businesses.

A final ruling against Google could set a major precedent, influencing future enforcement actions and shaping the regulatory landscape for global tech companies operating within Europe.

As scrutiny intensifies, the outcome of the investigation is expected to play a critical role in defining the future of digital competition across the European Union.

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AI & Technology

Amazon Faces Potential Criminal Trial in Italy Over €1.2 Billion Tax Evasion Allegations

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Milan: U.S. tech giant Amazon is facing the prospect of a major legal showdown in Italy, after prosecutors in Milan formally requested a court to move forward with criminal proceedings over alleged tax evasion totaling approximately ₹12,500 crore (€1.2 billion).

The case targets Amazon’s European division along with four senior executives, marking one of the most significant tax-related investigations involving a global e-commerce platform in Europe.

Trial Push Despite Multi-Million Euro Settlement

The move comes even after Amazon reached a financial settlement with Italian tax authorities in December, agreeing to pay around ₹5,500 crore (€527 million), including interest, to resolve part of the dispute.

Typically, such settlements lead to the closure of criminal investigations. However, Milan prosecutors have opted to proceed, signaling a tougher stance on alleged corporate tax violations.

A preliminary hearing is expected in the coming months, where a judge will decide whether to formally indict the company and its executives or dismiss the case.

Allegations of VAT Evasion Through Marketplace Sellers

At the center of the investigation are claims that Amazon’s platform enabled non-European Union sellers to avoid paying value-added tax (VAT) on goods sold to Italian consumers between 2019 and 2021.

Prosecutors allege that the company’s marketplace structure allowed thousands of foreign vendors—many reportedly based in China—to operate without fully disclosing their identities or tax obligations. This, authorities argue, led to substantial VAT losses for the Italian government.

Under Italian law, online platforms facilitating sales can be held partially liable if third-party sellers fail to comply with tax requirements, a key point in the prosecution’s case.

Italian Government Named as Affected Party

In their filing, prosecutors identified Italy’s Economy Ministry as the injured party, citing significant financial damage resulting from the alleged tax evasion.

Legal experts say the outcome of the case could have wide-ranging implications across the European Union, where VAT systems are harmonized and similar compliance rules apply to digital marketplaces.

Multiple Investigations Add to Pressure

The VAT probe is just one of several legal challenges facing Amazon in Italy. The European Public Prosecutor’s Office is reportedly examining additional tax-related issues covering more recent years.

Meanwhile, Milan authorities are pursuing separate investigations into alleged customs fraud linked to imports from China and whether Amazon maintained an undeclared “permanent establishment” in Italy—potentially exposing it to higher tax liabilities.

In a separate regulatory action, Italy’s data protection authority recently ordered an Amazon unit to stop using personal data from over 1,800 employees at a warehouse near Rome.

Amazon Denies Allegations

Amazon has consistently denied wrongdoing and indicated it will strongly contest the allegations in court if the case proceeds. The company has also warned that prolonged legal uncertainty could impact investor confidence and Italy’s appeal as a destination for international business.

Broader Impact on Europe’s Digital Economy

If the case moves to trial, it could become a landmark moment for the regulation of global e-commerce platforms in Europe. Governments across the region are increasingly scrutinizing how digital marketplaces handle tax compliance, especially in cross-border transactions.

With online retail continuing to expand, regulators are under mounting pressure to ensure that multinational platforms and third-party sellers adhere to the same tax rules as traditional businesses.

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Aviation

IndiGo Crisis Exposes Risks of Monopoly: What If Telecom or E-commerce Collapses Next?

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Airports across India witnessed scenes of distress and confusion as thousands of passengers were stranded due to IndiGo’s massive flight disruptions. Families with medical emergencies, funerals, and personal crises were left helpless as the airline cancelled hundreds of flights without adequate communication or support.

Passengers described desperate situations — a mother pleading for sanitary pads for her daughter, a woman unable to transport her husband’s coffin, and others stranded while trying to reach family funerals or hospitals. “It was like a lockdown at the airport,” one passenger said, describing the panic that unfolded as IndiGo’s mismanagement crippled operations nationwide.

Root Cause: IndiGo’s Market Monopoly

The turmoil, industry experts argue, stems from IndiGo’s monopolistic control over India’s domestic aviation market. The airline operates nearly 2,100 flights daily and holds around 60% market share — meaning every second plane flying within India belongs to IndiGo.

This dominance has given the company unparalleled influence. When IndiGo falters, the entire aviation system suffers. Passengers are left with few alternatives, as other airlines lack capacity to absorb stranded travellers. The result: skyrocketing ticket prices, chaos at terminals, and total dependence on a single private operator.

Aviation pioneer Captain G.R. Gopinath, founder of Air Deccan, criticised the government’s inaction, noting that on some routes, IndiGo’s economy fares surged to ₹1 lakh. He compared the situation to a hostage crisis, writing that the airline “held the system ransom” and forced regulators to defer new safety rules meant to protect pilots and passengers.

Government Intervention and Regulatory Weakness

The crisis erupted after IndiGo failed to comply with the Flight Duty Time Limitations (FDTL) — rules introduced by the DGCA in January 2024 requiring adequate rest for pilots. Despite having nearly two years to adapt, IndiGo blamed the rule for operational disruptions, citing a shortage of pilots.

Under mounting public pressure, the government stepped in, temporarily relaxing FDTL norms and capping airfare hikes. Officials claimed the move was to protect passengers, but analysts say it exposed the state’s vulnerability to corporate monopolies. “The government had no option but to yield,” said one aviation policy expert, pointing out that ignoring safety regulations for short-term relief could have long-term consequences.

The crisis also rekindled memories of the June 2025 Air India crash near London, which claimed over 240 lives. Experts warn that compromising pilot rest and safety standards to maintain flight schedules could risk another tragedy.

If Telecom Giants Fail: A National Paralysis

The article raises a troubling question — what if a similar crisis struck the telecom sector, where Jio and Airtel together control nearly 80% of subscribers and serve over 780 million users?

If both networks failed simultaneously, the repercussions would be catastrophic. Internet shutdowns would halt UPI transactions, online banking, OTP verifications, video calls, OTT streaming, and emergency communications. Critical services such as airports, hospitals, stock exchanges, and small businesses — many of which rely on WhatsApp and digital payments — would come to a standstill.

In essence, a telecom breakdown could paralyse India’s digital economy, exposing the nation’s dependence on a duopoly.

E-commerce Monopoly: Another Fragile Ecosystem

The same risk looms over the e-commerce sector, where Amazon and Flipkart dominate nearly 80% of the market. A disruption similar to IndiGo’s could cripple daily life — halting delivery of groceries, medicines, and essential goods, freezing refunds and customer support, and leaving small sellers without platforms to trade.

Local retailers, freed from competition, might exploit shortages by inflating prices. Such a scenario underscores the perils of market centralisation in sectors critical to everyday living.

A Wake-Up Call for Regulators

The IndiGo crisis, analysts say, is a warning shot for policymakers and regulators. A single company’s operational failure exposed systemic weaknesses in India’s infrastructure and consumer protection mechanisms.

As the aviation regulator DGCA investigates and IndiGo works to restore normalcy, the broader lesson remains clear: unchecked monopoly power in any essential service — whether air travel, telecom, or e-commerce — poses a direct threat to economic stability and citizen welfare.

Without stronger competition laws, redundancy frameworks, and regulatory oversight, India risks repeating this crisis across multiple sectors — each time with millions of citizens paying the price.

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