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Can Psychedelics Cure or Treat Fibromyalgia? – Safety Trial Begins on New Psychedelic Compound for Fibromylgia

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Tripping balls to treat fibromyalgia, could it be a breakthrough?

The probability of treating fibromyalgia with psychedelics in the nearest future has significantly increased following Silo Pharma Inc’s latest announcement about its novel psychedelic compound, which is still in its developmental stage. The reputable pharmaceutical company has begun dosing its newest formulation of Ketamine SP-26, which will be used topically to cure or manage fibromyalgia.

The research team at Silo, the fast-rising developmental-stage psychedelics biotech company, also specified that they would use an IND-enabling study of proprietary time releases while administering the compound during this safety trial.

Overview of Fibromyalgia

Fibromyalgia is one of many disease conditions that affect the nervous system and result in chronic pain or fatigue. Patients who have Fibromyalgia often experience widespread tenderness and ranging levels of pain in their muscles, joints, and other areas of their bodies. Medical researchers and practitioners have explained that Fibromyalgia is not an autoimmune disease; however, they are yet to understand the underlying cause of the complex condition fully.

Fibromyalgia is often confused with Multiple Sclerosis because they possess similar symptoms like muscle weaknesses; however, they are different disease conditions. For instance, Fibromyalgia pain could range from a dull ache to a cascading pain and can be accompanied by tender muscle or tendon spots. Other unique symptoms include restless leg syndrome, chronic fatigue, and fibro fog, otherwise known as a sense of confusion. Before a patient can be officially diagnosed with fibromyalgia, they must have exhibited most of these symptoms for at least three months.

At the time of writing, Fibromyalgia remains a long-term condition with no cure but can be managed with specific medications. These medications help to reduce the patient’s symptoms and improve their general quality of life. According to the American College of Rheumatology, the best methods for managing Fibromyalgia include medical therapy, physical exercises, mental health support, and enough sleep. The latest lift of restrictions on psychedelics has more or less positioned psychedelic compounds as an alternative way to treat Fibromyalgia. And Silo has taken up this challenge.

Silo’s Latest Efforts

In their recent publication, Silo disclosed that the proposed safety evaluation trial to test the suitability of its just-developed novel psychedelic compound would be carried out by a renowned frontage company known as Experimur. The trial will assess the tolerability of SP-26 to determine the right amount of dose that can be administered to a patient. The trial will establish the minimum and maximum dose for a Fibromyalgia patient.

Seeing as the chronic medical condition also causes sleep difficulties, memory loss, and widespread musculoskeletal pain, the team seeks to determine the standard dose administration that can reduce the symptoms and improve the patient’s quality of life.

Eric Weisblum, CEO of Silo Pharmaceuticals Inc, stated in an interview that the company is more than excited to cross this milestone. He acknowledged their partner, Zulo therapeutics, a South Carolina pharma, for working successfully with them till this point. He further spoke of how both companies have successfully developed a new method to efficiently deliver the psychedelic formulation, ketamine, via a time-released sequence. He noted that the novel drug showed a superior ability to reduce neuropathic nerve pains during the project’s pre-clinical studies.

According to Eric, this IND-backed study will help bring the research team closer to testing the novel formulation in real-life fibromyalgia patients.

It is worth noting that Silo Pharma and its regulatory partner are moving forward with their plans to register a pre-investigational New Drug (IND) package submission  SP-26 to the FDA via the 505(b)(2) regulatory pathway. This request specified one or more clinical or nonclinical studies that are required for approval but have not yet been completed by the applicant and for which the applicant lacks the right of reference.

Psychedelics: The Future of Fibromyalgia therapy?

The market for fibromyalgia therapies was estimated by Fortune Business Insights to be worth $764 million in 2020 and $1.4 billion in 2027, with a Compound Annual Growth Rate (CAGR) of 9.2% within the next five years. This shows a massive market for psychedelic producers to fill and profit from while improving thousands of lives.

To some patients, using psychedelics for fibromyalgia may seem weird, but with the development from Silo researchers and others, it’s becoming more apparent that these compounds may help. The FDA may soon allow psychedelic medications like psilocybin and NMDA, according to several researchers.

The Chronic Pain & Fatigue Research Center at the University of Michigan, which has unparalleled experience evaluating treatments for fibromyalgia and other chronic pain indications, explained that nothing is more important to their team than developing psychedelic and psilocybin therapies that will address the daily distress of patients.

In a similar trial to the Silo team’s proposed research, the research center evaluated the safety and efficacy of Tryp’s TRYP-8802 oral formulation of synthetic psilocybin. The treatment also included psychotherapy to address pain through neuroplasticity, which alters and reorganizes neural networks in the brain. At the time, Tryp President and Chief Science Officer Jim Gilligan told the media that he was thrilled to work with other forward-thinking doctors and scientists to provide alternative treatments for common painful conditions like fibromyalgia and multiple sclerosis.

Last year, another pharmaceutical company, Mind Medicine (MindMed), announced plans to study LSD as a treatment for cluster headaches and an unidentified “common, sometimes devastating, chronic pain condition.”

For companies like Silo and Tryp, their objective is to develop psilocybin-based medications to meet unmet medical demands for the treatment of diverse diseases like chronic pain/fatigue and eating problems.

Bottom Line

Fibromyalgia leaves people with extensive physical pain, tiredness, sleepless nights, anxiety, and despair. With upcoming clinical and safety trials, it might be safe to say that psychedelic compounds like SP-26 will join the two most popular treatments for fibromyalgia, non-steroidal anti-inflammatory drugs (NSAIDs) and gabapentinoids (Lyrica, Neurontin), to provide relief for patients. On the plus side, patients will be able to survive without enduring the unpleasant side effects of conventional drugs.

Meanwhile, the use of psychedelics to treat medical conditions, particularly mental health conditions, including anxiety, depression, and other mental health issues, has gained popularity in recent years. In years, LSD, psilocybin, and other psychedelics may also be helpful for pain relief in modest doses.

Source: https://cannabis.net/blog/medical/can-psychedelics-cure-or-treat-fibromyalgia-safety-trial-begins-on-new-psychedelic-compound-for

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Jio’s 1,600-Satellite LEO Constellation Gets Technical Green Light

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Reliance Jio has crossed a significant milestone in its space connectivity ambitions after its proposal to deploy a Low Earth Orbit (LEO) satellite constellation of around 1,600 satellites received a positive technical assessment from the Indian National Space Promotion and Authorisation Centre (IN-SPACe).

The evaluation, conducted jointly by IN-SPACe, the Indian Space Research Organisation (ISRO), and the Wireless Planning and Coordination (WPC) wing of the Department of Telecommunications, reportedly concluded that Jio’s proposed system meets the required technical standards and is comparable to leading global satellite broadband networks.

India’s Indigenous LEO Satellite Vision

Under the proposal, Reliance Jio plans to deploy between 1,600 and 1,650 satellites in Low Earth Orbit at an altitude of around 650 kilometres.

The planned constellation is expected to provide high-speed satellite connectivity across India, with approximately 32 satellites visible from any location at a given time. The company aims to roll out the network within the next two to three years, subject to regulatory approvals.

According to industry estimates, the satellite system could deliver 4.5 to 5 terabits per second (Tbps) of total data capacity, making it one of the largest satellite broadband projects proposed in India.

The project is expected to require an investment of $10–15 billion (approximately ₹95,000 crore to ₹1.42 lakh crore), reflecting the scale of infrastructure needed for satellite manufacturing, launches, ground stations, and user terminals.

Regulatory Process Moves Forward

Following the successful technical review, the proposal is expected to move into the next phase of regulatory approvals.

The government may now assist Jio in securing orbital slots, coordinating spectrum usage, and filing applications with the International Telecommunication Union (ITU), the global body responsible for managing satellite orbit and frequency allocations.

Obtaining orbital rights remains a critical step, as Low Earth Orbit has become increasingly competitive due to the growing number of satellite broadband projects being planned worldwide.

Officials also indicated that the proposed satellite architecture has been designed to coexist with future Indian LEO constellations, allowing multiple domestic operators to share orbital resources efficiently.

Broadband, Mobile Connectivity, and Strategic Applications

Jio plans to use the satellite network to provide a range of communication services, including satellite broadband, mobile backhaul, enterprise connectivity, and direct-to-device (D2D) satellite communication, particularly in remote and underserved regions where conventional telecom infrastructure is limited.

The company also intends to establish 20 to 22 ground stations across India to support network operations.

Apart from commercial telecommunications, officials have highlighted the project’s potential strategic importance. A domestically developed satellite constellation could strengthen India’s communication infrastructure, reduce dependence on foreign satellite operators, and support national security requirements.

Reports suggest preliminary discussions are underway regarding the possibility of integrating defence-related payloads into some satellites, enabling both civilian and strategic use.

Major Step for India’s Space and Telecom Sectors

Industry analysts view the technical clearance as an important milestone in India’s expanding private space ecosystem. If Jio secures the remaining regulatory approvals and international orbital clearances, the project could become the country’s first large-scale indigenous LEO satellite broadband network.

The initiative also aligns with India’s broader efforts to expand digital connectivity while strengthening its presence in the global satellite communications market.

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Alleged Crores Pharma Scam Mastermind Arrested from Surat

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After evading law enforcement for nearly 13 years, an accused linked to a large-scale pharmaceutical fraud case has been arrested by Delhi Police from Surat, Gujarat. The suspect is alleged to have orchestrated a series of financial scams involving fake identities, forged documents, and dishonoured cheques used to procure high-value pharmaceutical raw materials.

Authorities say the accused, identified as Himmat Singh Lodha, is believed to have defrauded multiple pharmaceutical companies in Delhi of goods worth approximately ₹98 lakh before disappearing and remaining underground for years.

Fake Business Deals and Dishonoured Cheques Used in Fraud

Investigators claim the accused posed as a legitimate pharmaceutical trader and placed bulk orders for expensive drug ingredients, offering post-dated cheques as payment security.

In one documented case from 2013, he allegedly obtained around 550 kilograms of Gliclazide, a diabetes-related pharmaceutical ingredient, valued at over ₹26 lakh. When suppliers attempted to encash the cheques, they were reportedly returned with the remark “account closed.”

Following the transaction, the accused allegedly vacated his office and rented residence and disappeared without settling payments. He was later declared a proclaimed offender in 2016 after repeatedly failing to appear before court proceedings. Authorities had also issued a reward for information leading to his arrest.

Multiple Identities and Repeated Fraud Pattern

Police investigations further link the accused to another cheating case dating back to 2012, where he allegedly used a fake identity, “Kailash Jain,” to obtain a large consignment of Ambroxol HCL, a pharmaceutical compound used in cough medications. The value of that consignment was estimated at around ₹72 lakh.

Officials believe the accused followed a consistent modus operandi—posing as a credible businessman, securing high-value goods on deferred payment terms, and then disappearing after delivery while shutting down business operations.

Investigators suspect that forged business records, fake company credentials, and fabricated financial histories were used to build trust with suppliers and gain access to expensive raw materials.

Multi-State Surveillance Leads to Arrest in Surat

A special Crime Branch team tracked the accused through coordinated surveillance efforts across multiple cities, including Mumbai, Ahmedabad, and Surat. After nearly a month of technical monitoring and intelligence gathering, officials located and arrested him from a residential area in Surat.

Authorities also revealed that the accused had been involved in property-related activities while staying under the radar to avoid detection.

Growing Threat of Corporate Identity Fraud

The case highlights a rising trend of organised financial fraud targeting industries that rely heavily on trust-based transactions and deferred payments. Experts note that criminals increasingly exploit gaps in corporate verification systems by using fake GST registrations, temporary offices, and forged documentation to appear legitimate.

Cybercrime and financial fraud specialists warn that such schemes are becoming more complex with the widespread availability of digital business tools, making it easier to create convincing but fraudulent corporate identities.

Experts Urge Stronger Due Diligence in High-Value Transactions

Experts, including former IPS officer and cybercrime specialist Prof. Triveni Singh, emphasize the need for stricter verification procedures in commercial dealings. He noted that relying solely on paperwork or digital business profiles can expose companies to significant financial risk.

Authorities and industry experts recommend physical verification of business operations, bank account validation, and detailed background checks before engaging in high-value or deferred-payment transactions—particularly in sectors like pharmaceuticals, where single consignments can involve transactions worth crores.

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EU Pressure Builds on Google as Regulators Face Calls for Massive Fine Over Search Practices

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A growing coalition of European industry groups is intensifying pressure on regulators to take decisive action against Google over allegations of unfair search practices that could reshape competition rules across the region’s digital economy.

Investigation Under Digital Markets Act Gains Momentum

The case is being examined by the European Commission under the European Union’s landmark Digital Markets Act (DMA), introduced to curb the dominance of major technology platforms and ensure fair competition.

Launched in March 2024, the investigation focuses on whether Google has been prioritising its own services in search results, potentially disadvantaging rival businesses that rely on online visibility to reach customers.

Industry Groups Demand Swift Action

Several prominent European organizations have jointly urged regulators to conclude the probe without further delay. They argue that prolonged investigations allow alleged anti-competitive practices to continue, putting European companies—especially startups—at a disadvantage.

Signatories include the European Publishers Council, the European Magazine Media Association, the European Tech Alliance, and EU Travel Tech.

In a joint statement, these groups warned that delays in enforcement are affecting innovation, profitability, and growth prospects for regional businesses competing in digital markets.

Google Denies Allegations

Google has rejected claims of bias, stating that its search algorithms are designed to deliver the most relevant and useful results to users. The company has also proposed adjustments to address regulatory concerns.

However, critics argue that these changes are insufficient and fail to address the core issue of market dominance.

Potential Billion-Euro Penalties

If found in violation of the DMA, Google could face significant financial penalties. Under EU rules, fines can reach a substantial percentage of a company’s global turnover, potentially amounting to billions of euros.

Regulators may also impose corrective measures requiring changes to business practices, which could have long-term implications for how digital platforms operate in Europe.

Wider Implications for Big Tech

The case highlights ongoing tensions between European regulators and major U.S. technology firms. In recent years, the EU has taken a more aggressive stance in enforcing competition laws, aiming to create a level playing field for local businesses.

A final ruling against Google could set a major precedent, influencing future enforcement actions and shaping the regulatory landscape for global tech companies operating within Europe.

As scrutiny intensifies, the outcome of the investigation is expected to play a critical role in defining the future of digital competition across the European Union.

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