Business
A Brave New World
Flourish Labs is testing legal psilocybin in Oregon.
When Oregon voters passed Proposition 109 in 2020, they cleared a path for greater access to the therapeutic use of psilocybin mushrooms and products that contain their active compounds. The ballot measure, which was approved with more than 55% of the vote, authorized the Oregon Health Authority (OHA) to create a program to permit licensed service providers to produce and administer psilocybin-producing mushroom products to adults 21 years of age or older.
A model for progressive drug policy reform, Prop. 109 also laid the groundwork for a new industry in Oregon. The OHA’s Psilocybin Services Section is charged with drafting rules to license and regulate the manufacturing, transportation, delivery, sale, and purchase of psilocybin products as well as the provision of psilocybin services, with a mandate to have the program up and running in 2023. The agency is already accepting applications for psilocybin business licenses and savvy entrepreneurs are launching new enterprises to service a rising industry.
A New Business is Born
George Sellhorn, founder and principal scientist at Flourish Labs in Portland, is one of the business owners preparing for the launch of legal psilocybin in Oregon. He has had a personal relationship with psychedelics, including psilocybin mushrooms, since he was a teenager and acknowledges that psychedelics have had a “huge impact” on his life. He is also an avid cannabis enthusiast and, with tips and encouragement from High Times, has been growing his own plants since 1993. His interest in and passion for cannabis inspired his academic pursuits, with Sellhorn earning a Ph.D. in plant biochemistry from the University of Washington in 2006.
At that time, the legal cannabis industry in the U.S. was in its infancy, and positions in professional fields were few and far between. Sellhorn turned to biotechnology to begin his career, with stints working on cancer therapeutics and an HIV vaccine. Before long, however, friends with businesses in the emerging industry encouraged him to open a cannabis testing lab. Intent on seeing where his chosen path would take, he decided against going into business for himself, although he did dabble in the industry a bit and helped a couple of friends get labs set up. It seemed right for Sellhorn at the time, but it didn’t take long for him to wish he had decided differently.
“A few years later, I kind of was kicking myself saying, ‘I probably should have started a lab, and I’d probably be a lot happier than I am right now,’” he tells me in a telephone interview.
After the passage of Prop. 109, things came full circle. Once again, friends in a soon-to-be legal industry encouraged him to open a lab. The ballot measure includes provisions directing the OHA’s regulations for testing psilocybin products for contamination. Additionally, therapists would want to know the dosage of active compounds they were administering, leading to a need for potency data throughout the supply chain.
Sellhorn remembers thinking, “I’ve been down this road before,” and decided he wouldn’t leave himself open to later regrets this time around. He began ordering the lab equipment and supplies he would need to launch the operation in September 2021, and by the beginning of 2022, Flourish Labs was ready to start taking in samples and running tests.
Sellhorn says that testing mushrooms is quite similar to lab analysis of cannabis, but with one key difference. Like many cannabis labs, Sellhorn uses high-performance liquid chromatography incorporated with ultra-violet spectroscopy (HPLC-UV) to separate the molecules of a given sample and determine its makeup. However, unlike cannabinoids, which are fat-soluble (hydrophobic), the alkaloids in mushrooms are water-soluble (hydrophilic), necessitating a change in the approach to make it work. “So, same methods as cannabis, but just the opposite chemistry,” Sellhorn summarizes.
Lab Testing for Psilocybin, and More
Much of the time Sellhorn spends in testing involves determining the amount of psychoactive alkaloids, or potency, a particular sample contains. More than 50 species of mushrooms produce psilocybin, which is expressed at different levels determined by factors including genetics and cultivation practices.
“The most potent mushroom that I’ve seen from different people is an Albino Penis Envy or an APE,” says Sellhorn. “Eve tested anywhere from 0.1% alkaloids, up to 2.3% was the highest one that I’ve tested so far. So, there’s a pretty big range. The average, I’d say, is about 0.5% to 0.7% alkaloids [by dry weight].”
Initially, Sellhorn’s business plan primarily involved analyzing mushrooms that contain psilocybin and related alkaloids, including psilocin, psilocybin, norpsilocin, baeocystin, and norbaeocystin. Since opening Flourish Labs, he has also developed testing protocols for other products made with psilocybin mushrooms that are likely to be part of Oregon’s upcoming regulated market.
“I can also do fruiting bodies and gummies, chocolates, and extracts, whether it be liquid extract or dry extract” he explains. “So, I have a protocol for all of the possible products that could be made, that I’m aware of, as of now.”
Dosage is Key
Sellhorn notes that the renewed interest in the reported health and wellness benefits of psilocybin has fostered a new culture of microdosing, which Sellhorn has been practicing for more than four years. To microdose, only a tiny fraction of a psychedelic dose of psilocybin is taken, perhaps 0.1 to 0.2 milligrams, Sellhorn suggests. With mushrooms of average potency (rounded up to 1% total alkaloids), that translates to about a tenth to two-tenths of a gram of mushroom biomass. “That’s like a really nice microdose, and you can adjust it based on body weight,” he says. “A microdose should be enough to lift your mood but not feel any of the psychedelic effects like you’re about to trip.”
At the other end of the spectrum is macrodosing, which involves taking enough psilocybin to produce a strong psychedelic effect, which can either be a heck of a fun trip or a space for life-changing spiritual or psychological breakthroughs, depending on the intention with which the drug is taken. To macrodose, Sellhorn says a dosage of 30 milligrams to 50 milligrams of psilocybin (approximately 5 grams of mushroom biomass) should be about right for an intense trip. And within the extremes of micro and macrodosing, “there’s doses in between there for whatever you’re looking for.”
In addition to potency, Sellhorn notes that the form of psilocybin taken can also influence the effects of the drug. While eating dried mushrooms is the classic method of consumption, extracted psilocybin and products made from it can modify the drug’s effects.
“It’s abundantly clear to me now that the mushroom biomass itself acts like a time-release capsule. So, if you take a mushroom that has, say, five milligrams of psilocybin in it, and you eat that, you’ll get a certain effect,” he explains. “And it’ll take a certain amount of time to hit you. But if you take five milligrams in a gummy or a chocolate, it hits you way faster, it’s much more intense, and it gets over more quickly.”
Sellhorn’s work in the lab has given him an opportunity to increase his knowledge about other psilocybin best practices, as well. He notes that proper storage is very effective at preserving the potency of psilocybin mushrooms. When a client was looking for data on potency degradation, an in-house study determined that mushrooms stored in a vacuum-sealed bag and kept in dark conditions at 60° Fahrenheit retained 98% of their potency after four months.
An Expanding Scientific Field
Although he sees a strong market for analyzing psilocybin-containing mushrooms coming to Oregon, Sellhorn realized that demand for lab testing may be limited until the industry is more established and generating revenue. Although the state’s regulations will likely eventually include requirements for testing for microbial contamination or the presence of heavy metals in addition to potency, such testing is not yet in high demand. So, to supplement his business plan, Flourish Labs has also begun lab testing of so-called functional mushrooms including cordyceps, reishi, and amanita muscaria (famous in folklore and pop culture) for compounds that could have health and wellness benefits. Additional species to be tested by the lab in the coming months include lion’s mane, chaga, maitake, tremella, and turkey tail.
When regulated production and administration of psilocybin for therapeutic purposes begins in Oregon later this year, it will launch a new industry in the state and become a milestone in the continued evolution of drug policy reform. Leading the way will be a new generation of innovators and entrepreneurs, including Sellhorn and Flourish Labs.
Source: https://hightimes.com/news/oregon/a-brave-new-world/
Business
Alleged Crores Pharma Scam Mastermind Arrested from Surat
After evading law enforcement for nearly 13 years, an accused linked to a large-scale pharmaceutical fraud case has been arrested by Delhi Police from Surat, Gujarat. The suspect is alleged to have orchestrated a series of financial scams involving fake identities, forged documents, and dishonoured cheques used to procure high-value pharmaceutical raw materials.
Authorities say the accused, identified as Himmat Singh Lodha, is believed to have defrauded multiple pharmaceutical companies in Delhi of goods worth approximately ₹98 lakh before disappearing and remaining underground for years.
Fake Business Deals and Dishonoured Cheques Used in Fraud
Investigators claim the accused posed as a legitimate pharmaceutical trader and placed bulk orders for expensive drug ingredients, offering post-dated cheques as payment security.
In one documented case from 2013, he allegedly obtained around 550 kilograms of Gliclazide, a diabetes-related pharmaceutical ingredient, valued at over ₹26 lakh. When suppliers attempted to encash the cheques, they were reportedly returned with the remark “account closed.”
Following the transaction, the accused allegedly vacated his office and rented residence and disappeared without settling payments. He was later declared a proclaimed offender in 2016 after repeatedly failing to appear before court proceedings. Authorities had also issued a reward for information leading to his arrest.
Multiple Identities and Repeated Fraud Pattern
Police investigations further link the accused to another cheating case dating back to 2012, where he allegedly used a fake identity, “Kailash Jain,” to obtain a large consignment of Ambroxol HCL, a pharmaceutical compound used in cough medications. The value of that consignment was estimated at around ₹72 lakh.
Officials believe the accused followed a consistent modus operandi—posing as a credible businessman, securing high-value goods on deferred payment terms, and then disappearing after delivery while shutting down business operations.
Investigators suspect that forged business records, fake company credentials, and fabricated financial histories were used to build trust with suppliers and gain access to expensive raw materials.
Multi-State Surveillance Leads to Arrest in Surat
A special Crime Branch team tracked the accused through coordinated surveillance efforts across multiple cities, including Mumbai, Ahmedabad, and Surat. After nearly a month of technical monitoring and intelligence gathering, officials located and arrested him from a residential area in Surat.
Authorities also revealed that the accused had been involved in property-related activities while staying under the radar to avoid detection.
Growing Threat of Corporate Identity Fraud
The case highlights a rising trend of organised financial fraud targeting industries that rely heavily on trust-based transactions and deferred payments. Experts note that criminals increasingly exploit gaps in corporate verification systems by using fake GST registrations, temporary offices, and forged documentation to appear legitimate.
Cybercrime and financial fraud specialists warn that such schemes are becoming more complex with the widespread availability of digital business tools, making it easier to create convincing but fraudulent corporate identities.
Experts Urge Stronger Due Diligence in High-Value Transactions
Experts, including former IPS officer and cybercrime specialist Prof. Triveni Singh, emphasize the need for stricter verification procedures in commercial dealings. He noted that relying solely on paperwork or digital business profiles can expose companies to significant financial risk.
Authorities and industry experts recommend physical verification of business operations, bank account validation, and detailed background checks before engaging in high-value or deferred-payment transactions—particularly in sectors like pharmaceuticals, where single consignments can involve transactions worth crores.
Business
EU Pressure Builds on Google as Regulators Face Calls for Massive Fine Over Search Practices
A growing coalition of European industry groups is intensifying pressure on regulators to take decisive action against Google over allegations of unfair search practices that could reshape competition rules across the region’s digital economy.
Investigation Under Digital Markets Act Gains Momentum
The case is being examined by the European Commission under the European Union’s landmark Digital Markets Act (DMA), introduced to curb the dominance of major technology platforms and ensure fair competition.
Launched in March 2024, the investigation focuses on whether Google has been prioritising its own services in search results, potentially disadvantaging rival businesses that rely on online visibility to reach customers.
Industry Groups Demand Swift Action
Several prominent European organizations have jointly urged regulators to conclude the probe without further delay. They argue that prolonged investigations allow alleged anti-competitive practices to continue, putting European companies—especially startups—at a disadvantage.
Signatories include the European Publishers Council, the European Magazine Media Association, the European Tech Alliance, and EU Travel Tech.
In a joint statement, these groups warned that delays in enforcement are affecting innovation, profitability, and growth prospects for regional businesses competing in digital markets.
Google Denies Allegations
Google has rejected claims of bias, stating that its search algorithms are designed to deliver the most relevant and useful results to users. The company has also proposed adjustments to address regulatory concerns.
However, critics argue that these changes are insufficient and fail to address the core issue of market dominance.
Potential Billion-Euro Penalties
If found in violation of the DMA, Google could face significant financial penalties. Under EU rules, fines can reach a substantial percentage of a company’s global turnover, potentially amounting to billions of euros.
Regulators may also impose corrective measures requiring changes to business practices, which could have long-term implications for how digital platforms operate in Europe.
Wider Implications for Big Tech
The case highlights ongoing tensions between European regulators and major U.S. technology firms. In recent years, the EU has taken a more aggressive stance in enforcing competition laws, aiming to create a level playing field for local businesses.
A final ruling against Google could set a major precedent, influencing future enforcement actions and shaping the regulatory landscape for global tech companies operating within Europe.
As scrutiny intensifies, the outcome of the investigation is expected to play a critical role in defining the future of digital competition across the European Union.
AI & Technology
Amazon Faces Potential Criminal Trial in Italy Over €1.2 Billion Tax Evasion Allegations
Milan: U.S. tech giant Amazon is facing the prospect of a major legal showdown in Italy, after prosecutors in Milan formally requested a court to move forward with criminal proceedings over alleged tax evasion totaling approximately ₹12,500 crore (€1.2 billion).
The case targets Amazon’s European division along with four senior executives, marking one of the most significant tax-related investigations involving a global e-commerce platform in Europe.
Trial Push Despite Multi-Million Euro Settlement
The move comes even after Amazon reached a financial settlement with Italian tax authorities in December, agreeing to pay around ₹5,500 crore (€527 million), including interest, to resolve part of the dispute.
Typically, such settlements lead to the closure of criminal investigations. However, Milan prosecutors have opted to proceed, signaling a tougher stance on alleged corporate tax violations.
A preliminary hearing is expected in the coming months, where a judge will decide whether to formally indict the company and its executives or dismiss the case.
Allegations of VAT Evasion Through Marketplace Sellers
At the center of the investigation are claims that Amazon’s platform enabled non-European Union sellers to avoid paying value-added tax (VAT) on goods sold to Italian consumers between 2019 and 2021.
Prosecutors allege that the company’s marketplace structure allowed thousands of foreign vendors—many reportedly based in China—to operate without fully disclosing their identities or tax obligations. This, authorities argue, led to substantial VAT losses for the Italian government.
Under Italian law, online platforms facilitating sales can be held partially liable if third-party sellers fail to comply with tax requirements, a key point in the prosecution’s case.
Italian Government Named as Affected Party
In their filing, prosecutors identified Italy’s Economy Ministry as the injured party, citing significant financial damage resulting from the alleged tax evasion.
Legal experts say the outcome of the case could have wide-ranging implications across the European Union, where VAT systems are harmonized and similar compliance rules apply to digital marketplaces.
Multiple Investigations Add to Pressure
The VAT probe is just one of several legal challenges facing Amazon in Italy. The European Public Prosecutor’s Office is reportedly examining additional tax-related issues covering more recent years.
Meanwhile, Milan authorities are pursuing separate investigations into alleged customs fraud linked to imports from China and whether Amazon maintained an undeclared “permanent establishment” in Italy—potentially exposing it to higher tax liabilities.
In a separate regulatory action, Italy’s data protection authority recently ordered an Amazon unit to stop using personal data from over 1,800 employees at a warehouse near Rome.
Amazon Denies Allegations
Amazon has consistently denied wrongdoing and indicated it will strongly contest the allegations in court if the case proceeds. The company has also warned that prolonged legal uncertainty could impact investor confidence and Italy’s appeal as a destination for international business.
Broader Impact on Europe’s Digital Economy
If the case moves to trial, it could become a landmark moment for the regulation of global e-commerce platforms in Europe. Governments across the region are increasingly scrutinizing how digital marketplaces handle tax compliance, especially in cross-border transactions.
With online retail continuing to expand, regulators are under mounting pressure to ensure that multinational platforms and third-party sellers adhere to the same tax rules as traditional businesses.
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