Business
A Brave New World
Flourish Labs is testing legal psilocybin in Oregon.
When Oregon voters passed Proposition 109 in 2020, they cleared a path for greater access to the therapeutic use of psilocybin mushrooms and products that contain their active compounds. The ballot measure, which was approved with more than 55% of the vote, authorized the Oregon Health Authority (OHA) to create a program to permit licensed service providers to produce and administer psilocybin-producing mushroom products to adults 21 years of age or older.
A model for progressive drug policy reform, Prop. 109 also laid the groundwork for a new industry in Oregon. The OHA’s Psilocybin Services Section is charged with drafting rules to license and regulate the manufacturing, transportation, delivery, sale, and purchase of psilocybin products as well as the provision of psilocybin services, with a mandate to have the program up and running in 2023. The agency is already accepting applications for psilocybin business licenses and savvy entrepreneurs are launching new enterprises to service a rising industry.
A New Business is Born
George Sellhorn, founder and principal scientist at Flourish Labs in Portland, is one of the business owners preparing for the launch of legal psilocybin in Oregon. He has had a personal relationship with psychedelics, including psilocybin mushrooms, since he was a teenager and acknowledges that psychedelics have had a “huge impact” on his life. He is also an avid cannabis enthusiast and, with tips and encouragement from High Times, has been growing his own plants since 1993. His interest in and passion for cannabis inspired his academic pursuits, with Sellhorn earning a Ph.D. in plant biochemistry from the University of Washington in 2006.
At that time, the legal cannabis industry in the U.S. was in its infancy, and positions in professional fields were few and far between. Sellhorn turned to biotechnology to begin his career, with stints working on cancer therapeutics and an HIV vaccine. Before long, however, friends with businesses in the emerging industry encouraged him to open a cannabis testing lab. Intent on seeing where his chosen path would take, he decided against going into business for himself, although he did dabble in the industry a bit and helped a couple of friends get labs set up. It seemed right for Sellhorn at the time, but it didn’t take long for him to wish he had decided differently.
“A few years later, I kind of was kicking myself saying, ‘I probably should have started a lab, and I’d probably be a lot happier than I am right now,’” he tells me in a telephone interview.
After the passage of Prop. 109, things came full circle. Once again, friends in a soon-to-be legal industry encouraged him to open a lab. The ballot measure includes provisions directing the OHA’s regulations for testing psilocybin products for contamination. Additionally, therapists would want to know the dosage of active compounds they were administering, leading to a need for potency data throughout the supply chain.
Sellhorn remembers thinking, “I’ve been down this road before,” and decided he wouldn’t leave himself open to later regrets this time around. He began ordering the lab equipment and supplies he would need to launch the operation in September 2021, and by the beginning of 2022, Flourish Labs was ready to start taking in samples and running tests.
Sellhorn says that testing mushrooms is quite similar to lab analysis of cannabis, but with one key difference. Like many cannabis labs, Sellhorn uses high-performance liquid chromatography incorporated with ultra-violet spectroscopy (HPLC-UV) to separate the molecules of a given sample and determine its makeup. However, unlike cannabinoids, which are fat-soluble (hydrophobic), the alkaloids in mushrooms are water-soluble (hydrophilic), necessitating a change in the approach to make it work. “So, same methods as cannabis, but just the opposite chemistry,” Sellhorn summarizes.
Lab Testing for Psilocybin, and More
Much of the time Sellhorn spends in testing involves determining the amount of psychoactive alkaloids, or potency, a particular sample contains. More than 50 species of mushrooms produce psilocybin, which is expressed at different levels determined by factors including genetics and cultivation practices.
“The most potent mushroom that I’ve seen from different people is an Albino Penis Envy or an APE,” says Sellhorn. “Eve tested anywhere from 0.1% alkaloids, up to 2.3% was the highest one that I’ve tested so far. So, there’s a pretty big range. The average, I’d say, is about 0.5% to 0.7% alkaloids [by dry weight].”
Initially, Sellhorn’s business plan primarily involved analyzing mushrooms that contain psilocybin and related alkaloids, including psilocin, psilocybin, norpsilocin, baeocystin, and norbaeocystin. Since opening Flourish Labs, he has also developed testing protocols for other products made with psilocybin mushrooms that are likely to be part of Oregon’s upcoming regulated market.
“I can also do fruiting bodies and gummies, chocolates, and extracts, whether it be liquid extract or dry extract” he explains. “So, I have a protocol for all of the possible products that could be made, that I’m aware of, as of now.”
Dosage is Key
Sellhorn notes that the renewed interest in the reported health and wellness benefits of psilocybin has fostered a new culture of microdosing, which Sellhorn has been practicing for more than four years. To microdose, only a tiny fraction of a psychedelic dose of psilocybin is taken, perhaps 0.1 to 0.2 milligrams, Sellhorn suggests. With mushrooms of average potency (rounded up to 1% total alkaloids), that translates to about a tenth to two-tenths of a gram of mushroom biomass. “That’s like a really nice microdose, and you can adjust it based on body weight,” he says. “A microdose should be enough to lift your mood but not feel any of the psychedelic effects like you’re about to trip.”
At the other end of the spectrum is macrodosing, which involves taking enough psilocybin to produce a strong psychedelic effect, which can either be a heck of a fun trip or a space for life-changing spiritual or psychological breakthroughs, depending on the intention with which the drug is taken. To macrodose, Sellhorn says a dosage of 30 milligrams to 50 milligrams of psilocybin (approximately 5 grams of mushroom biomass) should be about right for an intense trip. And within the extremes of micro and macrodosing, “there’s doses in between there for whatever you’re looking for.”
In addition to potency, Sellhorn notes that the form of psilocybin taken can also influence the effects of the drug. While eating dried mushrooms is the classic method of consumption, extracted psilocybin and products made from it can modify the drug’s effects.
“It’s abundantly clear to me now that the mushroom biomass itself acts like a time-release capsule. So, if you take a mushroom that has, say, five milligrams of psilocybin in it, and you eat that, you’ll get a certain effect,” he explains. “And it’ll take a certain amount of time to hit you. But if you take five milligrams in a gummy or a chocolate, it hits you way faster, it’s much more intense, and it gets over more quickly.”
Sellhorn’s work in the lab has given him an opportunity to increase his knowledge about other psilocybin best practices, as well. He notes that proper storage is very effective at preserving the potency of psilocybin mushrooms. When a client was looking for data on potency degradation, an in-house study determined that mushrooms stored in a vacuum-sealed bag and kept in dark conditions at 60° Fahrenheit retained 98% of their potency after four months.
An Expanding Scientific Field
Although he sees a strong market for analyzing psilocybin-containing mushrooms coming to Oregon, Sellhorn realized that demand for lab testing may be limited until the industry is more established and generating revenue. Although the state’s regulations will likely eventually include requirements for testing for microbial contamination or the presence of heavy metals in addition to potency, such testing is not yet in high demand. So, to supplement his business plan, Flourish Labs has also begun lab testing of so-called functional mushrooms including cordyceps, reishi, and amanita muscaria (famous in folklore and pop culture) for compounds that could have health and wellness benefits. Additional species to be tested by the lab in the coming months include lion’s mane, chaga, maitake, tremella, and turkey tail.
When regulated production and administration of psilocybin for therapeutic purposes begins in Oregon later this year, it will launch a new industry in the state and become a milestone in the continued evolution of drug policy reform. Leading the way will be a new generation of innovators and entrepreneurs, including Sellhorn and Flourish Labs.
Source: https://hightimes.com/news/oregon/a-brave-new-world/
Aviation
IndiGo Crisis Exposes Risks of Monopoly: What If Telecom or E-commerce Collapses Next?
Airports across India witnessed scenes of distress and confusion as thousands of passengers were stranded due to IndiGo’s massive flight disruptions. Families with medical emergencies, funerals, and personal crises were left helpless as the airline cancelled hundreds of flights without adequate communication or support.
Passengers described desperate situations — a mother pleading for sanitary pads for her daughter, a woman unable to transport her husband’s coffin, and others stranded while trying to reach family funerals or hospitals. “It was like a lockdown at the airport,” one passenger said, describing the panic that unfolded as IndiGo’s mismanagement crippled operations nationwide.
Root Cause: IndiGo’s Market Monopoly
The turmoil, industry experts argue, stems from IndiGo’s monopolistic control over India’s domestic aviation market. The airline operates nearly 2,100 flights daily and holds around 60% market share — meaning every second plane flying within India belongs to IndiGo.
This dominance has given the company unparalleled influence. When IndiGo falters, the entire aviation system suffers. Passengers are left with few alternatives, as other airlines lack capacity to absorb stranded travellers. The result: skyrocketing ticket prices, chaos at terminals, and total dependence on a single private operator.
Aviation pioneer Captain G.R. Gopinath, founder of Air Deccan, criticised the government’s inaction, noting that on some routes, IndiGo’s economy fares surged to ₹1 lakh. He compared the situation to a hostage crisis, writing that the airline “held the system ransom” and forced regulators to defer new safety rules meant to protect pilots and passengers.
Government Intervention and Regulatory Weakness
The crisis erupted after IndiGo failed to comply with the Flight Duty Time Limitations (FDTL) — rules introduced by the DGCA in January 2024 requiring adequate rest for pilots. Despite having nearly two years to adapt, IndiGo blamed the rule for operational disruptions, citing a shortage of pilots.
Under mounting public pressure, the government stepped in, temporarily relaxing FDTL norms and capping airfare hikes. Officials claimed the move was to protect passengers, but analysts say it exposed the state’s vulnerability to corporate monopolies. “The government had no option but to yield,” said one aviation policy expert, pointing out that ignoring safety regulations for short-term relief could have long-term consequences.
The crisis also rekindled memories of the June 2025 Air India crash near London, which claimed over 240 lives. Experts warn that compromising pilot rest and safety standards to maintain flight schedules could risk another tragedy.
If Telecom Giants Fail: A National Paralysis
The article raises a troubling question — what if a similar crisis struck the telecom sector, where Jio and Airtel together control nearly 80% of subscribers and serve over 780 million users?
If both networks failed simultaneously, the repercussions would be catastrophic. Internet shutdowns would halt UPI transactions, online banking, OTP verifications, video calls, OTT streaming, and emergency communications. Critical services such as airports, hospitals, stock exchanges, and small businesses — many of which rely on WhatsApp and digital payments — would come to a standstill.
In essence, a telecom breakdown could paralyse India’s digital economy, exposing the nation’s dependence on a duopoly.
E-commerce Monopoly: Another Fragile Ecosystem
The same risk looms over the e-commerce sector, where Amazon and Flipkart dominate nearly 80% of the market. A disruption similar to IndiGo’s could cripple daily life — halting delivery of groceries, medicines, and essential goods, freezing refunds and customer support, and leaving small sellers without platforms to trade.
Local retailers, freed from competition, might exploit shortages by inflating prices. Such a scenario underscores the perils of market centralisation in sectors critical to everyday living.
A Wake-Up Call for Regulators
The IndiGo crisis, analysts say, is a warning shot for policymakers and regulators. A single company’s operational failure exposed systemic weaknesses in India’s infrastructure and consumer protection mechanisms.
As the aviation regulator DGCA investigates and IndiGo works to restore normalcy, the broader lesson remains clear: unchecked monopoly power in any essential service — whether air travel, telecom, or e-commerce — poses a direct threat to economic stability and citizen welfare.
Without stronger competition laws, redundancy frameworks, and regulatory oversight, India risks repeating this crisis across multiple sectors — each time with millions of citizens paying the price.
Agriculture & Life Sciences
Canada’s Cannabis Industry Urges Government to Support Growing Export Market
BuzzBuzz Cannabis Business News — 24 November 2025
Canada’s cannabis sector is calling on federal and provincial governments to recognize its fast-growing export potential and extend the same support other regulated industries receive. Industry leaders warn that Canada is losing its early global advantage due to slow regulatory processes, lack of trade promotion, and limited access to government-backed financing.
Canada’s medical-cannabis exporters now generate more than half a billion dollars annually and ship products to major markets including Germany, the UK, Australia, and Poland. Despite this, cannabis remains largely absent from Canada’s official trade and export strategies.
Industry Calls for Streamlined Export System
Paul McCarthy, President of the Cannabis Council of Canada, says the country has everything required to dominate the global medical cannabis trade—except government alignment.
“Our requests are simple,” McCarthy said. “Expedite Health Canada’s export-permit process, integrate cannabis into federal export programs like Global Affairs Canada trade missions and CanExport, and ensure provinces include cannabis in their export strategies.”
He stressed the need for mutual recognition agreements with importing countries to eliminate redundant testing and documentation. Access to Export Development Canada (EDC) and Business Development Bank of Canada (BDC) services also remains off-limits to cannabis exporters, placing them at a steep disadvantage.
“This industry does not just need permission to operate,” McCarthy added. “It needs to be treated like every other legitimate contributor to Canada’s trade objectives.”
Competitors Are Moving Faster
McCarthy warns that while Canada pioneered medical cannabis standards, other countries are rapidly advancing with more flexible and export-friendly systems.
“Faster approvals, lower compliance costs, and active government-backed strategies are helping other nations catch up,” he said. “Canada’s regulatory friction is already costing us global market share.”
Export permits currently must be issued for each shipment—a process that can take weeks—and Canadian testing standards often differ from international requirements, forcing companies to repeat expensive compliance checks.
High Tide CEO: Canada Needs a National Export Strategy
Raj Grover, CEO of High Tide Inc., says Canada risks surrendering its leadership if policymakers remain inactive.
“Canada developed the world’s most advanced cannabis regulatory system and contributed $76.5 billion to GDP since legalization,” Grover said. “But without a National Cannabis Export Strategy, we will lose ground to Australia, Israel, Portugal, and other emerging competitors.”
He noted that Canada’s industry table created by Innovation, Science and Economic Development Canada (ISED) has not met in more than a year—an opportunity wasted.
Grover urged the federal government to introduce domestic GMP certification and potency standards to streamline international market access. “Canadian producers must currently get GMP approval country by country. It’s duplicative and costly. Canada should be setting global benchmarks, not chasing them.”
Germany: A Key Market for Canadian Firms
High Tide recently expanded into Europe with its majority acquisition of Germany’s Remexian Pharma GmbH, giving the company a direct import and distribution channel in Europe’s largest medical-cannabis market.
“Our German strategy is already structured for success,” Grover said. “Through Remexian, we can supply premium medical cannabis at the lowest possible price, helping meet Germany’s quality and cost demands.”
Grover also warned that U.S. companies are already purchasing Canadian firms to stage their own international expansion—another sign that Canada’s leadership position is slipping.
Government Response Remains Limited
In response to industry concerns, a Global Affairs Canada spokesperson said the Trade Commissioner Service “continues to support exporters of cannabis for medical and scientific purposes that have obtained Health Canada permits.”
However, industry leaders argue that this support is minimal and does not include key tools such as trade missions, export credits, or bilateral agreements that other sectors routinely receive.
A Closing Window of Opportunity
With medical-cannabis exports already exceeding $500 million annually, industry executives say Canada must act quickly to preserve its competitive edge.
As McCarthy warns, without coordinated government support, Canada risks losing high-value pharmaceutical manufacturing, research investments, and thousands of skilled jobs.
And as Grover’s expansion into Germany demonstrates, the industry is moving forward—but whether Canada moves with it may determine if the country remains a global leader or becomes a pioneer that let others capitalize on its breakthroughs.
Business
A Tipping Point for Cannabis: President Trump Champions CBD & Cannabis Science on Truth Social
When the President of the United States shares a video about the life changing potential of hemp derived CBD on his personal social media platform, it is more than news, it is a cultural shift.
For decades our government lied to us about cannabis. It demonized the plant, waged war on its users, and filled prisons while allowing pharmaceutical companies to flood the nation with addictive and deadly drugs. For over a century we have been fighting uphill, not just for legalization, but for truth, for science, and for the right to heal ourselves naturally.
Now in 2025, the most powerful political figure on Earth is using his own voice and platform to talk about the endocannabinoid system and the science backed benefits of CBD. That is monumental. It is validation for everyone who has fought, been arrested, been silenced, and been dismissed for telling this truth. The President’s video post is already being described as a pivotal moment in cannabis history, and President Trump CBD Cannabis Science Truth Social is trending across platforms as advocates celebrate the breakthrough.
The Science Behind the Endocannabinoid System
The video begins by introducing something most people, including many doctors, still know little about, the endocannabinoid system. Discovered in the 1990s, the ECS is a network of receptors and signaling molecules that works as the body’s master regulator, coordinating communication between major systems like the nervous, immune, cardiovascular, and digestive systems.
The roots of this discovery go back much further. CBD was first isolated in 1940 by American chemist Roger Adams, but it was Dr. Raphael Mechoulam, an Israeli organic chemist, who fully elucidated the chemical structure of CBD and identified its stereochemistry in the 1960s. His pioneering work not only opened the door to modern cannabinoid science but also earned him the title “Godfather of Cannabis Research.” It was this foundation that led to the identification of the endocannabinoid system itself decades later, revealing how cannabinoids interact with our physiology on a fundamental level.
The ECS is now widely recognized as a vital part of human biology, with extensive research supported by the National Institutes of Health. When functioning properly, the ECS acts like the conductor of an orchestra, ensuring every section plays in harmony. As we age, the system weakens. That imbalance is linked to inflammation, chronic pain, cognitive decline, sleep problems, and many other conditions associated with aging.
Mainstream medicine often addresses these issues with pharmaceutical band aids, dangerous and addictive drugs that treat symptoms rather than root causes. Lifestyle changes such as diet and exercise help, but they only partially support the ECS and do so slowly over time.
Hemp Derived CBD: A Game Changer for Aging
Here is where the science gets exciting. As the video explains, the ECS can be restored much more quickly with hemp derived CBD. Strengthening this system naturally helps the body regain balance, reducing pain, improving sleep, lowering stress, slowing disease progression, and even extending healthy lifespan.
It is not theoretical. One in five seniors is already using CBD to manage pain, arthritis, cancer symptoms, sleep disorders, Alzheimer’s, and more. Despite decades of research and acknowledgment from institutions like the National Institutes of Health, most physicians receive no training on the ECS. There are still no FDA standards for CBD products on the market. If that were the case for any other class of medicine, it would be considered malpractice.
The World Health Organization has confirmed CBD’s excellent safety profile and non addictive nature in its critical review report. The result is that millions of older Americans are suffering unnecessarily when a safe and natural solution exists.
Hemp derived CBD is a powerful first step in restoring balance to the endocannabinoid system, but it is only part of the picture. Research shows that full spectrum cannabis extracts, which include a broader range of cannabinoids and terpenes, can work even more effectively. Complete concentrated cannabis oil, containing the full spectrum of natural endocannabinoids, may deliver the most profound results for certain patients. Expanding access to these therapies will be essential if we want to unlock the full healing potential of this plant.
The Economic and Social Impact
The video cites a powerful figure. A PricewaterhouseCoopers analysis estimates that fully integrating cannabis into the healthcare system could save the United States nearly 64 billion dollars annually. These savings reflect reduced pharmaceutical dependency, fewer hospitalizations, improved chronic disease outcomes, and enhanced quality of life for aging Americans. You can read more about PwC’s research on healthcare innovation here.
It is a financial argument, but it is also a moral one. Why should our elders endure pain, anxiety, and cognitive decline when nature has given us tools to help them live longer, happier, and healthier lives?
A Call to Action: Finish What the Farm Bill Started
The message concludes by crediting the 2018 Farm Bill, championed by President Trump, for legalizing hemp and laying the groundwork for today’s CBD market. The Farm Bill was just the first step.
Now the call is for bold next moves.
- Educate doctors about the endocannabinoid system
- Include CBD under Medicare coverage
- Provide clear federal standards for CBD quality and dosing
These steps would constitute the most significant senior health reform in modern history, one that would transform aging and cement a powerful legacy for any administration that makes it happen.
What This Means for Future Cannabis Medicine
For those of us who have been in the cannabis community for decades, this is not just another news story. It is a signal that our movement is winning. A conversation that was once criminalized and censored is now being amplified by the President of the United States on his own platform.
It means the science is undeniable. It means the truth can no longer be buried. It means the wall of prohibition is cracking, not just legally, but culturally, scientifically, and politically.
It also means that everything we have been fighting for at 420 Magazine since 1993, education, access, healing, and justice, is finally moving full steam ahead. The President Trump CBD Cannabis Science Truth Social moment is proof that science and policy are finally converging.
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