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Want to Get an Extra Half-Hour of Sleep Every Night? – Microdosing LSD Leads to Close to 24 Minutes of Extra Sleep a Night

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Microdosing LSD may help millions get a better night sleep says new medical study

A groundbreaking study conducted by researchers from the University of Auckland in New Zealand has unveiled a potentially remarkable medical benefit of the mystical and potent hallucinogen lysergic acid diethylamide (LSD): its ability to enhance sleep. Titled “LSD Increases Sleep Duration the Night After Microdosing,” the study was published on June 28.

The findings revealed a significant improvement in sleep patterns, albeit with a delayed effect that manifested the day after the initial LSD experience had subsided.

The researchers carefully followed a group of 80 healthy adult male volunteers for the study over a period of six weeks. Every third day, self-administered doses of either a 10 g microdose of LSD or a placebo were given to these volunteers. Due to the tolerance building up to LSD’s effects, which normally last for two to three consecutive days as documented by MAPS, this dose regimen was consciously chosen.

The study concentrated on LSD microdoses, which are substantially smaller than the average recreational dose range of 50-250 g. Nonetheless, even at this lower dose, LSD had a more powerful effect than other hallucinogens.

Surprisingly, the researchers saw that the sleep patterns the next day had improved in a “clinically significant” way, including a rise in the amount of time spent in REM sleep. The most common stage of sleep, known as REM sleep, is when dreams typically take place.

Benefit of a Better Sleep Time

The researchers noted that participants who took a microdose of LSD the day before experienced significantly increased sleep duration compared to those in the placebo group. However, no differences in sleep were observed on the actual dosing day. The differences translated to an additional 8 minutes of REM sleep, 21 minutes of overall sleep time, and 24 minutes of total sleep time on the night following microdosing. Interestingly, participants in the LSD group went to bed earlier on the night after microdosing.

The study was authored by Nathan Allen, Aron Jeremiah, Robin Murphy, Rachael Sumner, Anna Forsyth, Nicholas Hoeh, David B Menkes, William Evans, Suresh Muthukumaraswamy, Frederick Sundram, and Partha Roop.

Furthermore, the authors highlighted that there were no differences in the distribution of sleep stages or physical activity between the LSD and placebo groups, nor any evidence of tolerance or altered sensation.

The researchers stressed the substantial implications of microdosing substances like LSD or psilocybin in the field of psychotherapy, delivered below the threshold for causing hallucinations. These consequences include improved mood and well-being, relief from anxiety and depression symptoms, and maybe increased creativity and productivity.

To monitor sleep duration throughout the study, a commercially available sleep/activity tracker was utilized. Analysis of sleep data from multiple nights demonstrated that participants in the LSD group slept an average of 24.3 minutes longer per night than those in the placebo group on the night following microdosing. No reductions in sleep were observed on the actual dosing day itself.

Implications for LSD in Medicine

The findings of this study reveal significant alterations in the physiological sleep requirements of healthy individuals who engage in microdosing. These findings have potential implications for the therapeutic effects of microdosing in mood disorders, specifically major depressive disorder, where sleep disturbances are commonly experienced. The objectively measured changes in sleep observed are distinct and clinically significant, making it difficult to attribute them to a mere placebo effect.

The authors acknowledged that previous microdosing studies have provided subjective reports regarding sleep quality. These studies have shown mixed results, with some participants reporting improvements in sleep while others experienced difficulties.

Furthermore, these findings are consistent with the positive sleep responses reported by MindBio Therapeutics earlier this month. Their study involved 80 participants in a clinical trial who were administered either a microdose of LSD or a placebo.

Additionally, in 2022, a New York-based biotech firm initiated a clinical trial to investigate the potential of LSD as a treatment for anxiety.

Unlocking LSD’s Therapeutic Potential: Exploring Promising Effects

The study’s results shed light on the intriguing therapeutic potential of LSD in the realm of medicine, particularly in addressing mood disorders and sleep disturbances. The significant changes observed in sleep patterns following microdosing suggest that LSD could offer valuable benefits for individuals struggling with conditions like major depressive disorder, where disrupted sleep is a common issue.

By extending sleep duration and enhancing REM sleep, LSD microdoses hold the promise of positively influencing mood and overall well-being. Given the crucial role of sleep in emotional regulation, the ability of LSD to improve sleep could potentially alleviate symptoms of depression and anxiety associated with these disorders.

Importantly, the objective measurements used in this study provide robust evidence beyond subjective reports, making it difficult to attribute the observed changes solely to a placebo effect. The clinically significant findings further reinforce the potential of LSD as a therapeutic agent.

These encouraging outcomes pave the way for continued research and exploration of LSD’s therapeutic potential. Ongoing studies and clinical trials, including the notable work by MindBio Therapeutics, are actively investigating the broader applications of LSD in treating various mental health conditions.

As our knowledge of LSD expands, it creates new opportunities for cutting-edge therapeutic techniques. With its emphasis on sub-threshold doses that maximize benefits while limiting hallucinogenic effects, microdosing has potential for boosting innovation, productivity, and general mental health.

While more research is needed to completely understand the underlying processes of LSD’s therapeutic effects, these findings lay a solid platform for future investigation. They underscore LSD’s potential as a significant medical tool, providing hope to patients seeking alternative therapies for mood disorders and sleep-related issues.

Bottom Line

The groundbreaking study conducted by researchers from the University of Auckland provides compelling evidence for the potential of microdoses of LSD in enhancing sleep duration and improving sleep patterns, particularly in individuals with mood disorders. The significant objective measurements of increased sleep time and improved REM sleep bolster the case for LSD’s therapeutic effects, surpassing placebo expectations. These findings offer new avenues for exploration and underscore the potential of LSD microdosing as a promising approach to alleviate sleep disturbances and enhance overall well-being in individuals grappling with mood disorders. Further research in this area holds great promise for advancing our understanding and utilization of LSD’s therapeutic potential in the realm of mental health.

Source: https://cannabis.net/blog/medical/want-to-get-an-extra-halfhour-of-sleep-every-night-microdosing-lsd-leads-to-close-to-24-minutes

Business

EU Pressure Builds on Google as Regulators Face Calls for Massive Fine Over Search Practices

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A growing coalition of European industry groups is intensifying pressure on regulators to take decisive action against Google over allegations of unfair search practices that could reshape competition rules across the region’s digital economy.

Investigation Under Digital Markets Act Gains Momentum

The case is being examined by the European Commission under the European Union’s landmark Digital Markets Act (DMA), introduced to curb the dominance of major technology platforms and ensure fair competition.

Launched in March 2024, the investigation focuses on whether Google has been prioritising its own services in search results, potentially disadvantaging rival businesses that rely on online visibility to reach customers.

Industry Groups Demand Swift Action

Several prominent European organizations have jointly urged regulators to conclude the probe without further delay. They argue that prolonged investigations allow alleged anti-competitive practices to continue, putting European companies—especially startups—at a disadvantage.

Signatories include the European Publishers Council, the European Magazine Media Association, the European Tech Alliance, and EU Travel Tech.

In a joint statement, these groups warned that delays in enforcement are affecting innovation, profitability, and growth prospects for regional businesses competing in digital markets.

Google Denies Allegations

Google has rejected claims of bias, stating that its search algorithms are designed to deliver the most relevant and useful results to users. The company has also proposed adjustments to address regulatory concerns.

However, critics argue that these changes are insufficient and fail to address the core issue of market dominance.

Potential Billion-Euro Penalties

If found in violation of the DMA, Google could face significant financial penalties. Under EU rules, fines can reach a substantial percentage of a company’s global turnover, potentially amounting to billions of euros.

Regulators may also impose corrective measures requiring changes to business practices, which could have long-term implications for how digital platforms operate in Europe.

Wider Implications for Big Tech

The case highlights ongoing tensions between European regulators and major U.S. technology firms. In recent years, the EU has taken a more aggressive stance in enforcing competition laws, aiming to create a level playing field for local businesses.

A final ruling against Google could set a major precedent, influencing future enforcement actions and shaping the regulatory landscape for global tech companies operating within Europe.

As scrutiny intensifies, the outcome of the investigation is expected to play a critical role in defining the future of digital competition across the European Union.

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Amazon Faces Potential Criminal Trial in Italy Over €1.2 Billion Tax Evasion Allegations

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Milan: U.S. tech giant Amazon is facing the prospect of a major legal showdown in Italy, after prosecutors in Milan formally requested a court to move forward with criminal proceedings over alleged tax evasion totaling approximately ₹12,500 crore (€1.2 billion).

The case targets Amazon’s European division along with four senior executives, marking one of the most significant tax-related investigations involving a global e-commerce platform in Europe.

Trial Push Despite Multi-Million Euro Settlement

The move comes even after Amazon reached a financial settlement with Italian tax authorities in December, agreeing to pay around ₹5,500 crore (€527 million), including interest, to resolve part of the dispute.

Typically, such settlements lead to the closure of criminal investigations. However, Milan prosecutors have opted to proceed, signaling a tougher stance on alleged corporate tax violations.

A preliminary hearing is expected in the coming months, where a judge will decide whether to formally indict the company and its executives or dismiss the case.

Allegations of VAT Evasion Through Marketplace Sellers

At the center of the investigation are claims that Amazon’s platform enabled non-European Union sellers to avoid paying value-added tax (VAT) on goods sold to Italian consumers between 2019 and 2021.

Prosecutors allege that the company’s marketplace structure allowed thousands of foreign vendors—many reportedly based in China—to operate without fully disclosing their identities or tax obligations. This, authorities argue, led to substantial VAT losses for the Italian government.

Under Italian law, online platforms facilitating sales can be held partially liable if third-party sellers fail to comply with tax requirements, a key point in the prosecution’s case.

Italian Government Named as Affected Party

In their filing, prosecutors identified Italy’s Economy Ministry as the injured party, citing significant financial damage resulting from the alleged tax evasion.

Legal experts say the outcome of the case could have wide-ranging implications across the European Union, where VAT systems are harmonized and similar compliance rules apply to digital marketplaces.

Multiple Investigations Add to Pressure

The VAT probe is just one of several legal challenges facing Amazon in Italy. The European Public Prosecutor’s Office is reportedly examining additional tax-related issues covering more recent years.

Meanwhile, Milan authorities are pursuing separate investigations into alleged customs fraud linked to imports from China and whether Amazon maintained an undeclared “permanent establishment” in Italy—potentially exposing it to higher tax liabilities.

In a separate regulatory action, Italy’s data protection authority recently ordered an Amazon unit to stop using personal data from over 1,800 employees at a warehouse near Rome.

Amazon Denies Allegations

Amazon has consistently denied wrongdoing and indicated it will strongly contest the allegations in court if the case proceeds. The company has also warned that prolonged legal uncertainty could impact investor confidence and Italy’s appeal as a destination for international business.

Broader Impact on Europe’s Digital Economy

If the case moves to trial, it could become a landmark moment for the regulation of global e-commerce platforms in Europe. Governments across the region are increasingly scrutinizing how digital marketplaces handle tax compliance, especially in cross-border transactions.

With online retail continuing to expand, regulators are under mounting pressure to ensure that multinational platforms and third-party sellers adhere to the same tax rules as traditional businesses.

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Aviation

IndiGo Crisis Exposes Risks of Monopoly: What If Telecom or E-commerce Collapses Next?

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Airports across India witnessed scenes of distress and confusion as thousands of passengers were stranded due to IndiGo’s massive flight disruptions. Families with medical emergencies, funerals, and personal crises were left helpless as the airline cancelled hundreds of flights without adequate communication or support.

Passengers described desperate situations — a mother pleading for sanitary pads for her daughter, a woman unable to transport her husband’s coffin, and others stranded while trying to reach family funerals or hospitals. “It was like a lockdown at the airport,” one passenger said, describing the panic that unfolded as IndiGo’s mismanagement crippled operations nationwide.

Root Cause: IndiGo’s Market Monopoly

The turmoil, industry experts argue, stems from IndiGo’s monopolistic control over India’s domestic aviation market. The airline operates nearly 2,100 flights daily and holds around 60% market share — meaning every second plane flying within India belongs to IndiGo.

This dominance has given the company unparalleled influence. When IndiGo falters, the entire aviation system suffers. Passengers are left with few alternatives, as other airlines lack capacity to absorb stranded travellers. The result: skyrocketing ticket prices, chaos at terminals, and total dependence on a single private operator.

Aviation pioneer Captain G.R. Gopinath, founder of Air Deccan, criticised the government’s inaction, noting that on some routes, IndiGo’s economy fares surged to ₹1 lakh. He compared the situation to a hostage crisis, writing that the airline “held the system ransom” and forced regulators to defer new safety rules meant to protect pilots and passengers.

Government Intervention and Regulatory Weakness

The crisis erupted after IndiGo failed to comply with the Flight Duty Time Limitations (FDTL) — rules introduced by the DGCA in January 2024 requiring adequate rest for pilots. Despite having nearly two years to adapt, IndiGo blamed the rule for operational disruptions, citing a shortage of pilots.

Under mounting public pressure, the government stepped in, temporarily relaxing FDTL norms and capping airfare hikes. Officials claimed the move was to protect passengers, but analysts say it exposed the state’s vulnerability to corporate monopolies. “The government had no option but to yield,” said one aviation policy expert, pointing out that ignoring safety regulations for short-term relief could have long-term consequences.

The crisis also rekindled memories of the June 2025 Air India crash near London, which claimed over 240 lives. Experts warn that compromising pilot rest and safety standards to maintain flight schedules could risk another tragedy.

If Telecom Giants Fail: A National Paralysis

The article raises a troubling question — what if a similar crisis struck the telecom sector, where Jio and Airtel together control nearly 80% of subscribers and serve over 780 million users?

If both networks failed simultaneously, the repercussions would be catastrophic. Internet shutdowns would halt UPI transactions, online banking, OTP verifications, video calls, OTT streaming, and emergency communications. Critical services such as airports, hospitals, stock exchanges, and small businesses — many of which rely on WhatsApp and digital payments — would come to a standstill.

In essence, a telecom breakdown could paralyse India’s digital economy, exposing the nation’s dependence on a duopoly.

E-commerce Monopoly: Another Fragile Ecosystem

The same risk looms over the e-commerce sector, where Amazon and Flipkart dominate nearly 80% of the market. A disruption similar to IndiGo’s could cripple daily life — halting delivery of groceries, medicines, and essential goods, freezing refunds and customer support, and leaving small sellers without platforms to trade.

Local retailers, freed from competition, might exploit shortages by inflating prices. Such a scenario underscores the perils of market centralisation in sectors critical to everyday living.

A Wake-Up Call for Regulators

The IndiGo crisis, analysts say, is a warning shot for policymakers and regulators. A single company’s operational failure exposed systemic weaknesses in India’s infrastructure and consumer protection mechanisms.

As the aviation regulator DGCA investigates and IndiGo works to restore normalcy, the broader lesson remains clear: unchecked monopoly power in any essential service — whether air travel, telecom, or e-commerce — poses a direct threat to economic stability and citizen welfare.

Without stronger competition laws, redundancy frameworks, and regulatory oversight, India risks repeating this crisis across multiple sectors — each time with millions of citizens paying the price.

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