Science
Study: Cannabinoids (THC/CBD) Beat Opioids In Managing Chronic Pain
When THC and CBD are combined in equal ratios, they provide a safer and more effective treatment for neuropathic pain compared to the traditional treatments.
Are cannabis-derived cannabinoids the ultimate panacea to the opioid crisis? A new study that was published recently in Cannabis and Cannabinoid Research has made interesting revelations on the safety and effectiveness of cannabinoids versus opioids in treating chronic pain.
From the study, it emerged that cannabinoids (THC and CBD) have a greater benefit-safety profile compared to opioids used to manage chronic neuropathic pain.
Neuropathic pain, simply known as nerve pain, is termed chronic when it persists for more than three months. The pain is usually sharp and burning and is likely to be debilitating. The causes vary and include diabetes and cystitis among others. Traditional treatment for neuropathic pain includes the use of anticonvulsants, antidepressants, and opioids.
The study was conducted by a team of pain specialists and psychiatrists, patient representatives, and scientists. 12 different pharmacological treatments including THC and CBD were considered for the study. The researchers sought to compare the safety and benefits of the drug compounds. The researchers created a model (multicriterion decision analysis) to score the performance of each drug in terms of safety and clinical benefits.
Here’s what the research revealed:

- A combination of THC and CBD in a ratio of 1:1 had the highest score (79)
- CBD dominant treatment followed with a score of 74
- THC dominant treatment came third with a score of 72
- Duloxetine and Gabapentin’s scored in the 60s
- Amitriptyline, Tramadol, and Ibuprofen scored in the 50s
- Methadone and Oxycodone scored in the 40s
- Morphine and Fentanyl scored in the 30s
An analysis of the results showed that a THC and CBD combination provided significantly higher safety benefits so much so that even if the pain reduction and quality of life score was halved it wouldn’t change the result.
What does this mean?
When THC and CBD are combined in equal ratios, they provide a safer and more effective treatment for neuropathic pain compared to the traditional treatments. While the combination had a score of 79, opioids had a score that ranged between the 30s- 60s. This supports previous research that suggests that cannabinoids can help with the opioid epidemic crisis that’s ravaging millions in its wake.
News
Study: Dispensaries Cut Down Heavy Drinking
As cannabis legalization expands across the United States, conversations continue to evolve about how increased access affects public health. A growing body of research now suggests that cannabis dispensaries may have a broader impact on community behavior than previously understood. Beyond simply providing regulated access to cannabis products, these retailers may influence patterns of alcohol use, particularly among adults who live nearby. Recent findings shed light on how shifts in cannabis policy can influence drinking habits and potentially contribute to healthier lifestyle outcomes.
Adults who reside in close proximity to licensed cannabis dispensaries are less likely to engage in binge drinking, according to data published in the American Journal of Preventive Medicine.
Oregon State University researchers assessed the relationship between local retail cannabis access and adults’ use of marijuana and alcohol over eight years.
They reported that proximity to cannabis retailers was associated with increased cannabis use by adults, but not by minors. They also reported that cannabis access was inversely associated with heavy alcohol use by young adults (those ages 21 to 24 years old) and seniors (those ages 65 and older).
“Consistent with substitution, … older adults and young adults showed access-related decreases in binge drinking,” the study’s authors reported.
They added: “Frequent or high-volume alcohol use causes myriad acute and lifelong health risks to drinkers and those around them. Therefore, a relative reduction in older and young adults’ high-risk drinking may be a net positive effect of shifting cannabis policies.”
The study’s conclusions are consistent with data published earlier this year, finding that many adults reduce their alcohol intake following the opening of state-licensed marijuana dispensaries.
These findings contribute to an increasingly nuanced picture of how cannabis dispensaries function within communities. Rather than promoting increased substance misuse, the presence of licensed cannabis retailers may encourage some adults to substitute cannabis for alcohol a shift that could potentially reduce the health risks associated with heavy drinking. While cannabis is not without its own considerations, regulated access may provide adults with an alternative that poses fewer long-term harms compared with chronic alcohol use.
As more states adopt regulated cannabis frameworks, researchers will continue exploring how these changes affect public health, safety, and substance use trends. For now, evidence suggests that cannabis dispensaries may play a surprising role in reducing harmful alcohol consumption among local adult populations. This research offers valuable insight for policymakers, health professionals, and communities navigating the evolving landscape of cannabis legalization.
Business
New Mexico cannabis operator fined, loses license for alleged BioTrack fraud
New Mexico regulators fined a cannabis operator nearly $300,000 and revoked its license after the company allegedly created fake reports in the state’s traceability software.
The New Mexico Cannabis Control Division (CCD) accused marijuana manufacturer and retailer Golden Roots of 11 violations, according to Albuquerque Business First.
Golden Roots operates the The Cannabis Revolution Dispensary.
The majority of the violations are related to the Albuquerque company’s improper use of BioTrack, which has been New Mexico’s track-and-trace vendor since 2015.
The CCD alleges Golden Roots reported marijuana production only two months after it had received its vertically integrated license, according to Albuquerque Business First.
Because cannabis takes longer than two months to be cultivated, the CCD was suspicious of the report.
After inspecting the company’s premises, the CCD alleged Golden Roots reported cultivation, transportation and sales in BioTrack but wasn’t able to provide officers who inspected the site evidence that the operator was cultivating cannabis.
In April, the CCD revoked Golden Roots’ license and issued a $10,000 fine, according to the news outlet.
The company requested a hearing, which the regulator scheduled for Sept. 1.
At the hearing, the CCD testified that the company’s dried-cannabis weights in BioTrack were suspicious because they didn’t seem to accurately reflect how much weight marijuana loses as it dries.
Company employees also poorly accounted for why they were making adjustments in the system of up to 24 pounds of cannabis, making comments such as “bad” or “mistake” in the software, Albuquerque Business First reported.
Golden Roots was fined $298,972.05 – the amount regulators allege the company made selling products that weren’t properly accounted for in BioTrack.
The CCD has been cracking down on cannabis operators accused of selling products procured from out-of-state or not grown legally:
- Regulators alleged in August that Albuquerque dispensary Sawmill Sweet Leaf sold out-of-state products and didn’t have a license for extraction.
- Paradise Exotics Distro lost its license in July after regulators alleged the company sold products made in California.
Golden Roots was the first alleged rulebreaker in New Mexico to be asked to pay a large fine.
Source: https://mjbizdaily.com/new-mexico-cannabis-operator-fined-loses-license-for-alleged-biotrack-fraud/
Business
Marijuana companies suing US attorney general in federal prohibition challenge
Four marijuana companies, including a multistate operator, have filed a lawsuit against U.S. Attorney General Merrick Garland in which they allege the federal MJ prohibition under the Controlled Substances Act is no longer constitutional.
According to the complaint, filed Thursday in U.S. District Court in Massachusetts, retailer Canna Provisions, Treevit delivery service CEO Gyasi Sellers, cultivator Wiseacre Farm and MSO Verano Holdings Corp. are all harmed by “the federal government’s unconstitutional ban on cultivating, manufacturing, distributing, or possessing intrastate marijuana.”
Verano is headquartered in Chicago but has operations in Massachusetts; the other three operators are based in Massachusetts.
The lawsuit seeks a ruling that the “Controlled Substances Act is unconstitutional as applied to the intrastate cultivation, manufacture, possession, and distribution of marijuana pursuant to state law.”
The companies want the case to go before the U.S. Supreme Court.
They hired prominent law firm Boies Schiller Flexner to represent them.
The New York-based firm’s principal is David Boies, whose former clients include Microsoft, former presidential candidate Al Gore and Elizabeth Holmes’ disgraced startup Theranos.
Similar challenges to the federal Controlled Substances Act (CSA) have failed.
One such challenge led to a landmark Supreme Court decision in 2005.
In Gonzalez vs. Raich, the highest court in the United States ruled in a 6-3 decision that the commerce clause of the U.S. Constitution gave Congress the power to outlaw marijuana federally, even though state laws allow the cultivation and sale of cannabis.
In the 18 years since that ruling, 23 states and the District of Columbia have legalized adult-use marijuana and the federal government has allowed a multibillion-dollar cannabis industry to thrive.
Since both Congress and the U.S. Department of Justice, currently headed by Garland, have declined to intervene in state-licensed marijuana markets, the key facts that led to the Supreme Court’s 2005 ruling “no longer apply,” Boies said in a statement Thursday.
“The Supreme Court has since made clear that the federal government lacks the authority to regulate purely intrastate commerce,” Boies said.
“Moreover, the facts on which those precedents are based are no longer true.”
Verano President Darren Weiss said in a statement the company is “prepared to bring this case all the way to the Supreme Court in order to align federal law with how Congress has acted for years.”
While the Biden administration’s push to reschedule marijuana would help solve marijuana operators’ federal tax woes, neither rescheduling nor modest Congressional reforms such as the SAFER Banking Act “solve the fundamental issue,” Weiss added.
“The application of the CSA to lawful state-run cannabis business is an unconstitutional overreach on state sovereignty that has led to decades of harm, failed businesses, lost jobs, and unsafe working conditions.”
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