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Is CBN The Fountain Of Youth? Here’s What A Recent Study Found

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Can the cannabinoid CBN help slow aging in brain cells, and protect the brain from age-related conditions?

It turns out that one of the ways your brain cells can remain sharp over time is with a steady dose of CBD. Some days back, the brilliant scientists at Salk revealed this fantastic discovery. They said that CBN, a minor and relatively unknown cannabinoid, has the potential to protect brain cells from the adverse impact of aging.

Research on medical cannabis has been going on for many decades. For the most of this duration, scientists have focused more on the therapeutic properties of major cannabinoid compounds (i.e. THC and CBD). Minor cannabinoids like cannabinol (CBN), cannabidiolic acid (CBDA), cannabigerolic acid (CBGA), acid (CBNA), cannabidivarin (CBDV), tetrahydrocannabivarin (THCV), cannabigerol (CBG), and acid (THCA) have been given less attention. We’ve begun to observe an influx of research into these minor compounds.

cannabis brain
Photo by Feodora Chiosea/Getty Images

Scientists say that these minor cannabinoids have more to offer medically. New researchers are investigating how these compounds are broken down and their interactions with the endocannabinoid system, emphasizing their effects on the brain.

Cannabinol and the Human Brain

Cannabinol has a similar molecular structure to THC, the major difference being that it is not psychoactive. The non-psychoactive property of the compound has caused it to be less regulated by federal agencies. The Salk researchers were pleased to announce their latest influential studies, which have established that cannabinol (CBN) positively impacts the brain. In the last decade, scientists around the world have tried to investigate the medical potential of CBN. However, the federal prohibition of the cannabis plant has limited these studies.

The primary pathway to the death of cells is through oxidative injuries. This is usually followed by neurologic disorders in aged people. This new study describes how cannabinol can shield brain cells, also called nerve cells, from the damaging effects of this pathway. The findings of this trial have been published in the online Free Radical Biology and Medicine journal. The detailed report implies that cannabinol could be an effective drug to treat or manage age-induced neurodegenerative diseases like Alzheimer’s. Scientists suggest that CBN has a high potential for protecting nerve cells as a person ages.

Salk Study Research

Professor Pamela Maher, senior author and head of Salk’s Cellular Neurobiology Laboratory, said her team had discovered the anti-neurodegenerative effects of cannabinol. She mentioned that her team studied how the cannabinoid shields nerve cells from oxidative stress and death, which are major contributors to the onset of dementia and Alzheimer’s diseases.

According to Neuroscience News, Maher and her team of brilliant researchers believe this discovery would lead to the development of new drugs and treatment plans to treat various neurodegenerative diseases, particularly Alzheimer’s and Parkinson’s. Maher’s lab had studied the use of cannabinol in the past, and this recent investigation was done to build on the first discoveries. In the preliminary research, the team found out about the protective properties of CBN on the brain and how CBN could be used to derive drugs for neurological diseases.

This recent study focused more on how CBN functions in the body. During this study, Salk scientists took into account the oxytosis and ferroptosis processes, a major contributing factor to aging and diseased brain cells. The oxytosis, or ferroptosis process occurs in aging brains. The mechanism is induced by the gradual loss of glutathione, an antioxidant, as a person ages. It results in prominent damage or death to neural cells through lip oxidation. The trial began by administering CBN to nerve cells to observe how they limit oxidative action. The scientists then proceeded to propose a different mechanism to induce oxidative damage.

Study Observations  

Following testing healthy and damaged brain cells with cannabinol, the following observations were made. The report stated that the administered cannabinol protected the nerve cells. They also observed that the mitochondria, a cell’s powerhouse, were protected from oxidative damage.

The mitochondria in healthy cells were compared with those in damaged cells. Maher and her team found that the mitochondria in the damaged cell appeared to be folded up in a round shape to shield it from more damage. These scrunched-up powerhouses are frequently noticed within the brain cells of Alzheimer’s and Parkinson’s patients.

Treating Dementia With Cannabis: What Patients And Caregivers Should Know
Photo by designer491/Getty Images

On the other hand, the healthy cells appropriately housed functioning mitochondria. The powerhouse in these cells remained in its regular, non-folded form.

Maher wrote that her team successfully showed that cannabinol could contribute to maintaining mitochondria in nerve cells. She added that the protective effects of CBN urged the proper functioning of the powerhouse.

More Information

Zhinin Liang, co-author and postdoctoral fellow, says that smoke evidence shows that cannabinol is safe for human and animal consumption. This can be linked to the absence of psychotropic effects after CBN is consumed. The researcher said that CBN works on specific cells in the body while delivering therapeutic effects.

Maher also noted that her team’s findings reveal implications for other neurodegenerative diseases connected to glutathione loss. The dysfunction of a nerve cell’s powerhouse results in further damage to nearby tissues. The potential of CBN to heal and maintain functions in a powerhouse suggests that it could also be used to treat other parts of the body besides the brain. This opens the floor for further research beyond the context of neurodegenerative conditions. The next agenda item for the team is to reproduce the above study in a preclinical mouse model.

Other researchers that contributed to the success of this study include Brendan Duggan from the University of California, Antonio Currais, David Schubert, Devin Kepchiaz, and David Soriano-Castell Salk. The Paul F. Glenn Center for Biology of Aging Research at Salk, the Shikey Foundation, the University of California, The Bundy Foundation, and the National Health Institute provided funding.

Bottom Line

Salk’s CBN research points out the need for more investigations into lesser-studied cannabinoids. Most of these minor cannabinoids have shown little therapeutic potential in the limited levels of research done.

Some of the therapeutic benefits possessed by CBN, as suggested by anecdotal evidence, include pain relief, stress relief, and anti-inflammatory effects. This buttresses Maher’s point that further comprehensive research must be done.

Source: https://420-reports.com/wp-admin/post.php?post=4857&action=edit

Business

EU Pressure Builds on Google as Regulators Face Calls for Massive Fine Over Search Practices

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A growing coalition of European industry groups is intensifying pressure on regulators to take decisive action against Google over allegations of unfair search practices that could reshape competition rules across the region’s digital economy.

Investigation Under Digital Markets Act Gains Momentum

The case is being examined by the European Commission under the European Union’s landmark Digital Markets Act (DMA), introduced to curb the dominance of major technology platforms and ensure fair competition.

Launched in March 2024, the investigation focuses on whether Google has been prioritising its own services in search results, potentially disadvantaging rival businesses that rely on online visibility to reach customers.

Industry Groups Demand Swift Action

Several prominent European organizations have jointly urged regulators to conclude the probe without further delay. They argue that prolonged investigations allow alleged anti-competitive practices to continue, putting European companies—especially startups—at a disadvantage.

Signatories include the European Publishers Council, the European Magazine Media Association, the European Tech Alliance, and EU Travel Tech.

In a joint statement, these groups warned that delays in enforcement are affecting innovation, profitability, and growth prospects for regional businesses competing in digital markets.

Google Denies Allegations

Google has rejected claims of bias, stating that its search algorithms are designed to deliver the most relevant and useful results to users. The company has also proposed adjustments to address regulatory concerns.

However, critics argue that these changes are insufficient and fail to address the core issue of market dominance.

Potential Billion-Euro Penalties

If found in violation of the DMA, Google could face significant financial penalties. Under EU rules, fines can reach a substantial percentage of a company’s global turnover, potentially amounting to billions of euros.

Regulators may also impose corrective measures requiring changes to business practices, which could have long-term implications for how digital platforms operate in Europe.

Wider Implications for Big Tech

The case highlights ongoing tensions between European regulators and major U.S. technology firms. In recent years, the EU has taken a more aggressive stance in enforcing competition laws, aiming to create a level playing field for local businesses.

A final ruling against Google could set a major precedent, influencing future enforcement actions and shaping the regulatory landscape for global tech companies operating within Europe.

As scrutiny intensifies, the outcome of the investigation is expected to play a critical role in defining the future of digital competition across the European Union.

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AI & Technology

Amazon Faces Potential Criminal Trial in Italy Over €1.2 Billion Tax Evasion Allegations

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Milan: U.S. tech giant Amazon is facing the prospect of a major legal showdown in Italy, after prosecutors in Milan formally requested a court to move forward with criminal proceedings over alleged tax evasion totaling approximately ₹12,500 crore (€1.2 billion).

The case targets Amazon’s European division along with four senior executives, marking one of the most significant tax-related investigations involving a global e-commerce platform in Europe.

Trial Push Despite Multi-Million Euro Settlement

The move comes even after Amazon reached a financial settlement with Italian tax authorities in December, agreeing to pay around ₹5,500 crore (€527 million), including interest, to resolve part of the dispute.

Typically, such settlements lead to the closure of criminal investigations. However, Milan prosecutors have opted to proceed, signaling a tougher stance on alleged corporate tax violations.

A preliminary hearing is expected in the coming months, where a judge will decide whether to formally indict the company and its executives or dismiss the case.

Allegations of VAT Evasion Through Marketplace Sellers

At the center of the investigation are claims that Amazon’s platform enabled non-European Union sellers to avoid paying value-added tax (VAT) on goods sold to Italian consumers between 2019 and 2021.

Prosecutors allege that the company’s marketplace structure allowed thousands of foreign vendors—many reportedly based in China—to operate without fully disclosing their identities or tax obligations. This, authorities argue, led to substantial VAT losses for the Italian government.

Under Italian law, online platforms facilitating sales can be held partially liable if third-party sellers fail to comply with tax requirements, a key point in the prosecution’s case.

Italian Government Named as Affected Party

In their filing, prosecutors identified Italy’s Economy Ministry as the injured party, citing significant financial damage resulting from the alleged tax evasion.

Legal experts say the outcome of the case could have wide-ranging implications across the European Union, where VAT systems are harmonized and similar compliance rules apply to digital marketplaces.

Multiple Investigations Add to Pressure

The VAT probe is just one of several legal challenges facing Amazon in Italy. The European Public Prosecutor’s Office is reportedly examining additional tax-related issues covering more recent years.

Meanwhile, Milan authorities are pursuing separate investigations into alleged customs fraud linked to imports from China and whether Amazon maintained an undeclared “permanent establishment” in Italy—potentially exposing it to higher tax liabilities.

In a separate regulatory action, Italy’s data protection authority recently ordered an Amazon unit to stop using personal data from over 1,800 employees at a warehouse near Rome.

Amazon Denies Allegations

Amazon has consistently denied wrongdoing and indicated it will strongly contest the allegations in court if the case proceeds. The company has also warned that prolonged legal uncertainty could impact investor confidence and Italy’s appeal as a destination for international business.

Broader Impact on Europe’s Digital Economy

If the case moves to trial, it could become a landmark moment for the regulation of global e-commerce platforms in Europe. Governments across the region are increasingly scrutinizing how digital marketplaces handle tax compliance, especially in cross-border transactions.

With online retail continuing to expand, regulators are under mounting pressure to ensure that multinational platforms and third-party sellers adhere to the same tax rules as traditional businesses.

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Aviation

IndiGo Crisis Exposes Risks of Monopoly: What If Telecom or E-commerce Collapses Next?

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Airports across India witnessed scenes of distress and confusion as thousands of passengers were stranded due to IndiGo’s massive flight disruptions. Families with medical emergencies, funerals, and personal crises were left helpless as the airline cancelled hundreds of flights without adequate communication or support.

Passengers described desperate situations — a mother pleading for sanitary pads for her daughter, a woman unable to transport her husband’s coffin, and others stranded while trying to reach family funerals or hospitals. “It was like a lockdown at the airport,” one passenger said, describing the panic that unfolded as IndiGo’s mismanagement crippled operations nationwide.

Root Cause: IndiGo’s Market Monopoly

The turmoil, industry experts argue, stems from IndiGo’s monopolistic control over India’s domestic aviation market. The airline operates nearly 2,100 flights daily and holds around 60% market share — meaning every second plane flying within India belongs to IndiGo.

This dominance has given the company unparalleled influence. When IndiGo falters, the entire aviation system suffers. Passengers are left with few alternatives, as other airlines lack capacity to absorb stranded travellers. The result: skyrocketing ticket prices, chaos at terminals, and total dependence on a single private operator.

Aviation pioneer Captain G.R. Gopinath, founder of Air Deccan, criticised the government’s inaction, noting that on some routes, IndiGo’s economy fares surged to ₹1 lakh. He compared the situation to a hostage crisis, writing that the airline “held the system ransom” and forced regulators to defer new safety rules meant to protect pilots and passengers.

Government Intervention and Regulatory Weakness

The crisis erupted after IndiGo failed to comply with the Flight Duty Time Limitations (FDTL) — rules introduced by the DGCA in January 2024 requiring adequate rest for pilots. Despite having nearly two years to adapt, IndiGo blamed the rule for operational disruptions, citing a shortage of pilots.

Under mounting public pressure, the government stepped in, temporarily relaxing FDTL norms and capping airfare hikes. Officials claimed the move was to protect passengers, but analysts say it exposed the state’s vulnerability to corporate monopolies. “The government had no option but to yield,” said one aviation policy expert, pointing out that ignoring safety regulations for short-term relief could have long-term consequences.

The crisis also rekindled memories of the June 2025 Air India crash near London, which claimed over 240 lives. Experts warn that compromising pilot rest and safety standards to maintain flight schedules could risk another tragedy.

If Telecom Giants Fail: A National Paralysis

The article raises a troubling question — what if a similar crisis struck the telecom sector, where Jio and Airtel together control nearly 80% of subscribers and serve over 780 million users?

If both networks failed simultaneously, the repercussions would be catastrophic. Internet shutdowns would halt UPI transactions, online banking, OTP verifications, video calls, OTT streaming, and emergency communications. Critical services such as airports, hospitals, stock exchanges, and small businesses — many of which rely on WhatsApp and digital payments — would come to a standstill.

In essence, a telecom breakdown could paralyse India’s digital economy, exposing the nation’s dependence on a duopoly.

E-commerce Monopoly: Another Fragile Ecosystem

The same risk looms over the e-commerce sector, where Amazon and Flipkart dominate nearly 80% of the market. A disruption similar to IndiGo’s could cripple daily life — halting delivery of groceries, medicines, and essential goods, freezing refunds and customer support, and leaving small sellers without platforms to trade.

Local retailers, freed from competition, might exploit shortages by inflating prices. Such a scenario underscores the perils of market centralisation in sectors critical to everyday living.

A Wake-Up Call for Regulators

The IndiGo crisis, analysts say, is a warning shot for policymakers and regulators. A single company’s operational failure exposed systemic weaknesses in India’s infrastructure and consumer protection mechanisms.

As the aviation regulator DGCA investigates and IndiGo works to restore normalcy, the broader lesson remains clear: unchecked monopoly power in any essential service — whether air travel, telecom, or e-commerce — poses a direct threat to economic stability and citizen welfare.

Without stronger competition laws, redundancy frameworks, and regulatory oversight, India risks repeating this crisis across multiple sectors — each time with millions of citizens paying the price.

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