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Do THC And CBD Offer More Therapeutic Benefits When Combined?

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One of the most striking things about the entourage effect is that it reinforces the idea that cannabis has a lot of potential.

The term “entourage effect” is commonly used in cannabis news articles, and it doesn’t mean a group of people who love weed or those who are cannabis enthusiasts. The term is used to describe the synergy between the combination of different chemical combinations in cannabis.

The entourage effect is about the interaction between THC/CBD as well as other terpenes and cannabinoids.

The basic terms

Cannabinoids

Cannabinoids interact with the body’s endocannabinoid system (ECS): a system made up of chemical parts called endocannabinoid and receptors in the body. These endocannabinoids and receptors aid with regulating the different body functions that include appetite, sleep, and pain.

THC is intoxicating. This is the cannabinoid that causes a ‘high” that many users feel after ingesting or inhaling cannabis. But CBD is not intoxicating, which explains why it is gaining a lot of popularity in the medical world. Many patients want to use cannabis for medicinal purposes but don’t want to feel high.

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Now the question is: do THC and CBD offer a more extensive range of therapeutic applications? In some cases, they work well together, and you are about to discover why as this is the core of the entourage effect.

Terpenes

One of the things cannabis enthusiasts find exciting with weed is how flavorful it is; the aroma that hits your face and warms you up when you open a cannabis container is just blissful. Do you know what is responsible for the fragrance? Its terpenes!! Good old terpenes.

Terpenes are the aromatic, flavorful compounds found in cannabis and other plants and spices, fruits, and herbs. From a hint of pepper to lavender and even pine terpenes offer a burst of flavors and aromas like no other compound will do.

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In cannabis plants, terpenes grow inside the resinous glands of the plant (this is called trichomes). The terpenes use their scents to protect the cannabis plant from predators, as most plant cannabis cannot handle the scent and flavor from the plant.

Terpenes also embody therapeutic properties, which explains why users feel a sense of calm and almost sleepy after taking a cannabis shot. An excellent example of this is the pinene terpenes found in pine trees: it reduces inflammation. The linalool terpenes found in lavender also provide anti-anxiety effects, and these are just examples of the therapeutic value of terpenes.

How the entourage effect works

We know that terpenes and cannabinoids offer particular effects on the human body, but what happens when you mix different cannabinoids or combine terpenes and cannabinoids?

As easy as the question sounds, the answer is not so easy, which means combining CBD and THC doesn’t mix the effects of both compounds. Instead, CBD and THC can interact with each other and other cannabinoids and terpenes to produce a synergy called the entourage effect.

Some people wonder which mixture of terpenes and cannabinoids is best for treating some health conditions. Cannabis had a much slower start because of many years of the stigma it received from societies, which led to prohibitions. These years of stigma delayed the research into the entourage effects.

Therefore, not much is known about cannabinoids and terpenes that will be a good pair and produce excellent results. Recently, some groundbreaking studies provide insight into how the entourage affects both cannabinoids and terpenes. We will consider both chemicals separately.

Entourage effects with terpenes

Dr. Ethan Russo presented a seminal research paper titled Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. 

His paper is critical in understanding the entourage effect, and the summaries from his studies showed the therapeutic effects of cannabinoids and terpenes.

terpenes
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Every terpene is distinct with its chemical composition, with every one of them offering something different. Some cannabis strains also contain various terpenes, making it complicated to know which cannabinoid-terpenes mix will elicit an entourage effect.

For instance, Dr. Russo also argues that the data shows that myrcene is the main sedative terpenoid in cannabis and, when combined with THC, will produce a form of the entourage effect. So if THC, when mixed with myrcene, has some potential for an entourage effect, one can only wonder what other kinds of combinations are possible.

Entourage effects with cannabis 

A study into the effectiveness of THC on how it reduces cancer-related pain versus when CBD and THC are combined discovered something interesting. The results show that THC and CBD combination displayed good effectiveness, unlike THC used in isolation.

The results are exciting and promising because they provide additional evidence of how the entourage effect can combine different cannabinoids.

Aside from amplifying the analgesic properties in THC, CBD also produces another very fun cannabinoid entourage effect. The results are shown through how it reduces the psychoactive effects of THC.

The process for how it works is also complex because CBD interacts indirectly with your body’s CB1 receptors in a way that also affects THC’s ability to bind with receptors.

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Photo by Kelly Sikkema via Unsplash

It is also important to remember some examples of the entourage effect when cannabinoid is combined. But most cannabis strains that are selectively bred are made to optimize THC and CBD content. So very little is known about the other cannabinoid (there are more than 118 cannabinoids). Which means there are much more potentials for the study of cannabinoid and terpenes if research continues on a large scale.

Bottom line 

One of the most striking things about the entourage effect is that it reinforces the idea that cannabis has a lot of potential. In the future, and as we learn more about the cannabis plant, we will know if it provides additional and impressive benefits for users.

We have discovered the value of CBD and THC separately, but now the world is eager to know, “How much more is there to discover with a combination of CBD and THC?”  The question will hopefully drive the extent of future research and test trials that will boost the positive impact of the entourage effect.

People want more and it is evident with the enormous amount of interest vested in cannabis.

Source: https://thefreshtoast.com/cannabis/cannabis-entourage-effect-fact-or-fiction/

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Business

EU Pressure Builds on Google as Regulators Face Calls for Massive Fine Over Search Practices

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A growing coalition of European industry groups is intensifying pressure on regulators to take decisive action against Google over allegations of unfair search practices that could reshape competition rules across the region’s digital economy.

Investigation Under Digital Markets Act Gains Momentum

The case is being examined by the European Commission under the European Union’s landmark Digital Markets Act (DMA), introduced to curb the dominance of major technology platforms and ensure fair competition.

Launched in March 2024, the investigation focuses on whether Google has been prioritising its own services in search results, potentially disadvantaging rival businesses that rely on online visibility to reach customers.

Industry Groups Demand Swift Action

Several prominent European organizations have jointly urged regulators to conclude the probe without further delay. They argue that prolonged investigations allow alleged anti-competitive practices to continue, putting European companies—especially startups—at a disadvantage.

Signatories include the European Publishers Council, the European Magazine Media Association, the European Tech Alliance, and EU Travel Tech.

In a joint statement, these groups warned that delays in enforcement are affecting innovation, profitability, and growth prospects for regional businesses competing in digital markets.

Google Denies Allegations

Google has rejected claims of bias, stating that its search algorithms are designed to deliver the most relevant and useful results to users. The company has also proposed adjustments to address regulatory concerns.

However, critics argue that these changes are insufficient and fail to address the core issue of market dominance.

Potential Billion-Euro Penalties

If found in violation of the DMA, Google could face significant financial penalties. Under EU rules, fines can reach a substantial percentage of a company’s global turnover, potentially amounting to billions of euros.

Regulators may also impose corrective measures requiring changes to business practices, which could have long-term implications for how digital platforms operate in Europe.

Wider Implications for Big Tech

The case highlights ongoing tensions between European regulators and major U.S. technology firms. In recent years, the EU has taken a more aggressive stance in enforcing competition laws, aiming to create a level playing field for local businesses.

A final ruling against Google could set a major precedent, influencing future enforcement actions and shaping the regulatory landscape for global tech companies operating within Europe.

As scrutiny intensifies, the outcome of the investigation is expected to play a critical role in defining the future of digital competition across the European Union.

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AI & Technology

Amazon Faces Potential Criminal Trial in Italy Over €1.2 Billion Tax Evasion Allegations

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Milan: U.S. tech giant Amazon is facing the prospect of a major legal showdown in Italy, after prosecutors in Milan formally requested a court to move forward with criminal proceedings over alleged tax evasion totaling approximately ₹12,500 crore (€1.2 billion).

The case targets Amazon’s European division along with four senior executives, marking one of the most significant tax-related investigations involving a global e-commerce platform in Europe.

Trial Push Despite Multi-Million Euro Settlement

The move comes even after Amazon reached a financial settlement with Italian tax authorities in December, agreeing to pay around ₹5,500 crore (€527 million), including interest, to resolve part of the dispute.

Typically, such settlements lead to the closure of criminal investigations. However, Milan prosecutors have opted to proceed, signaling a tougher stance on alleged corporate tax violations.

A preliminary hearing is expected in the coming months, where a judge will decide whether to formally indict the company and its executives or dismiss the case.

Allegations of VAT Evasion Through Marketplace Sellers

At the center of the investigation are claims that Amazon’s platform enabled non-European Union sellers to avoid paying value-added tax (VAT) on goods sold to Italian consumers between 2019 and 2021.

Prosecutors allege that the company’s marketplace structure allowed thousands of foreign vendors—many reportedly based in China—to operate without fully disclosing their identities or tax obligations. This, authorities argue, led to substantial VAT losses for the Italian government.

Under Italian law, online platforms facilitating sales can be held partially liable if third-party sellers fail to comply with tax requirements, a key point in the prosecution’s case.

Italian Government Named as Affected Party

In their filing, prosecutors identified Italy’s Economy Ministry as the injured party, citing significant financial damage resulting from the alleged tax evasion.

Legal experts say the outcome of the case could have wide-ranging implications across the European Union, where VAT systems are harmonized and similar compliance rules apply to digital marketplaces.

Multiple Investigations Add to Pressure

The VAT probe is just one of several legal challenges facing Amazon in Italy. The European Public Prosecutor’s Office is reportedly examining additional tax-related issues covering more recent years.

Meanwhile, Milan authorities are pursuing separate investigations into alleged customs fraud linked to imports from China and whether Amazon maintained an undeclared “permanent establishment” in Italy—potentially exposing it to higher tax liabilities.

In a separate regulatory action, Italy’s data protection authority recently ordered an Amazon unit to stop using personal data from over 1,800 employees at a warehouse near Rome.

Amazon Denies Allegations

Amazon has consistently denied wrongdoing and indicated it will strongly contest the allegations in court if the case proceeds. The company has also warned that prolonged legal uncertainty could impact investor confidence and Italy’s appeal as a destination for international business.

Broader Impact on Europe’s Digital Economy

If the case moves to trial, it could become a landmark moment for the regulation of global e-commerce platforms in Europe. Governments across the region are increasingly scrutinizing how digital marketplaces handle tax compliance, especially in cross-border transactions.

With online retail continuing to expand, regulators are under mounting pressure to ensure that multinational platforms and third-party sellers adhere to the same tax rules as traditional businesses.

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Aviation

IndiGo Crisis Exposes Risks of Monopoly: What If Telecom or E-commerce Collapses Next?

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Airports across India witnessed scenes of distress and confusion as thousands of passengers were stranded due to IndiGo’s massive flight disruptions. Families with medical emergencies, funerals, and personal crises were left helpless as the airline cancelled hundreds of flights without adequate communication or support.

Passengers described desperate situations — a mother pleading for sanitary pads for her daughter, a woman unable to transport her husband’s coffin, and others stranded while trying to reach family funerals or hospitals. “It was like a lockdown at the airport,” one passenger said, describing the panic that unfolded as IndiGo’s mismanagement crippled operations nationwide.

Root Cause: IndiGo’s Market Monopoly

The turmoil, industry experts argue, stems from IndiGo’s monopolistic control over India’s domestic aviation market. The airline operates nearly 2,100 flights daily and holds around 60% market share — meaning every second plane flying within India belongs to IndiGo.

This dominance has given the company unparalleled influence. When IndiGo falters, the entire aviation system suffers. Passengers are left with few alternatives, as other airlines lack capacity to absorb stranded travellers. The result: skyrocketing ticket prices, chaos at terminals, and total dependence on a single private operator.

Aviation pioneer Captain G.R. Gopinath, founder of Air Deccan, criticised the government’s inaction, noting that on some routes, IndiGo’s economy fares surged to ₹1 lakh. He compared the situation to a hostage crisis, writing that the airline “held the system ransom” and forced regulators to defer new safety rules meant to protect pilots and passengers.

Government Intervention and Regulatory Weakness

The crisis erupted after IndiGo failed to comply with the Flight Duty Time Limitations (FDTL) — rules introduced by the DGCA in January 2024 requiring adequate rest for pilots. Despite having nearly two years to adapt, IndiGo blamed the rule for operational disruptions, citing a shortage of pilots.

Under mounting public pressure, the government stepped in, temporarily relaxing FDTL norms and capping airfare hikes. Officials claimed the move was to protect passengers, but analysts say it exposed the state’s vulnerability to corporate monopolies. “The government had no option but to yield,” said one aviation policy expert, pointing out that ignoring safety regulations for short-term relief could have long-term consequences.

The crisis also rekindled memories of the June 2025 Air India crash near London, which claimed over 240 lives. Experts warn that compromising pilot rest and safety standards to maintain flight schedules could risk another tragedy.

If Telecom Giants Fail: A National Paralysis

The article raises a troubling question — what if a similar crisis struck the telecom sector, where Jio and Airtel together control nearly 80% of subscribers and serve over 780 million users?

If both networks failed simultaneously, the repercussions would be catastrophic. Internet shutdowns would halt UPI transactions, online banking, OTP verifications, video calls, OTT streaming, and emergency communications. Critical services such as airports, hospitals, stock exchanges, and small businesses — many of which rely on WhatsApp and digital payments — would come to a standstill.

In essence, a telecom breakdown could paralyse India’s digital economy, exposing the nation’s dependence on a duopoly.

E-commerce Monopoly: Another Fragile Ecosystem

The same risk looms over the e-commerce sector, where Amazon and Flipkart dominate nearly 80% of the market. A disruption similar to IndiGo’s could cripple daily life — halting delivery of groceries, medicines, and essential goods, freezing refunds and customer support, and leaving small sellers without platforms to trade.

Local retailers, freed from competition, might exploit shortages by inflating prices. Such a scenario underscores the perils of market centralisation in sectors critical to everyday living.

A Wake-Up Call for Regulators

The IndiGo crisis, analysts say, is a warning shot for policymakers and regulators. A single company’s operational failure exposed systemic weaknesses in India’s infrastructure and consumer protection mechanisms.

As the aviation regulator DGCA investigates and IndiGo works to restore normalcy, the broader lesson remains clear: unchecked monopoly power in any essential service — whether air travel, telecom, or e-commerce — poses a direct threat to economic stability and citizen welfare.

Without stronger competition laws, redundancy frameworks, and regulatory oversight, India risks repeating this crisis across multiple sectors — each time with millions of citizens paying the price.

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