Connect with us

Business

Do THC And CBD Offer More Therapeutic Benefits When Combined?

Published

on

One of the most striking things about the entourage effect is that it reinforces the idea that cannabis has a lot of potential.

The term “entourage effect” is commonly used in cannabis news articles, and it doesn’t mean a group of people who love weed or those who are cannabis enthusiasts. The term is used to describe the synergy between the combination of different chemical combinations in cannabis.

The entourage effect is about the interaction between THC/CBD as well as other terpenes and cannabinoids.

The basic terms

Cannabinoids

Cannabinoids interact with the body’s endocannabinoid system (ECS): a system made up of chemical parts called endocannabinoid and receptors in the body. These endocannabinoids and receptors aid with regulating the different body functions that include appetite, sleep, and pain.

THC is intoxicating. This is the cannabinoid that causes a ‘high” that many users feel after ingesting or inhaling cannabis. But CBD is not intoxicating, which explains why it is gaining a lot of popularity in the medical world. Many patients want to use cannabis for medicinal purposes but don’t want to feel high.

Will Congress Boost Hemp Total THC Limit To 1%?
Photo by anankkml/Getty Images

Now the question is: do THC and CBD offer a more extensive range of therapeutic applications? In some cases, they work well together, and you are about to discover why as this is the core of the entourage effect.

Terpenes

One of the things cannabis enthusiasts find exciting with weed is how flavorful it is; the aroma that hits your face and warms you up when you open a cannabis container is just blissful. Do you know what is responsible for the fragrance? Its terpenes!! Good old terpenes.

Terpenes are the aromatic, flavorful compounds found in cannabis and other plants and spices, fruits, and herbs. From a hint of pepper to lavender and even pine terpenes offer a burst of flavors and aromas like no other compound will do.

State Governments Are Starting To Ban Delta-8 THC
Photo by Christina Winter via Unsplash

In cannabis plants, terpenes grow inside the resinous glands of the plant (this is called trichomes). The terpenes use their scents to protect the cannabis plant from predators, as most plant cannabis cannot handle the scent and flavor from the plant.

Terpenes also embody therapeutic properties, which explains why users feel a sense of calm and almost sleepy after taking a cannabis shot. An excellent example of this is the pinene terpenes found in pine trees: it reduces inflammation. The linalool terpenes found in lavender also provide anti-anxiety effects, and these are just examples of the therapeutic value of terpenes.

How the entourage effect works

We know that terpenes and cannabinoids offer particular effects on the human body, but what happens when you mix different cannabinoids or combine terpenes and cannabinoids?

As easy as the question sounds, the answer is not so easy, which means combining CBD and THC doesn’t mix the effects of both compounds. Instead, CBD and THC can interact with each other and other cannabinoids and terpenes to produce a synergy called the entourage effect.

Some people wonder which mixture of terpenes and cannabinoids is best for treating some health conditions. Cannabis had a much slower start because of many years of the stigma it received from societies, which led to prohibitions. These years of stigma delayed the research into the entourage effects.

Therefore, not much is known about cannabinoids and terpenes that will be a good pair and produce excellent results. Recently, some groundbreaking studies provide insight into how the entourage affects both cannabinoids and terpenes. We will consider both chemicals separately.

Entourage effects with terpenes

Dr. Ethan Russo presented a seminal research paper titled Taming THC: Potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. 

His paper is critical in understanding the entourage effect, and the summaries from his studies showed the therapeutic effects of cannabinoids and terpenes.

terpenes
Photo by Kirill Vasikev/EyeEm/Getty Images

Every terpene is distinct with its chemical composition, with every one of them offering something different. Some cannabis strains also contain various terpenes, making it complicated to know which cannabinoid-terpenes mix will elicit an entourage effect.

For instance, Dr. Russo also argues that the data shows that myrcene is the main sedative terpenoid in cannabis and, when combined with THC, will produce a form of the entourage effect. So if THC, when mixed with myrcene, has some potential for an entourage effect, one can only wonder what other kinds of combinations are possible.

Entourage effects with cannabis 

A study into the effectiveness of THC on how it reduces cancer-related pain versus when CBD and THC are combined discovered something interesting. The results show that THC and CBD combination displayed good effectiveness, unlike THC used in isolation.

The results are exciting and promising because they provide additional evidence of how the entourage effect can combine different cannabinoids.

Aside from amplifying the analgesic properties in THC, CBD also produces another very fun cannabinoid entourage effect. The results are shown through how it reduces the psychoactive effects of THC.

The process for how it works is also complex because CBD interacts indirectly with your body’s CB1 receptors in a way that also affects THC’s ability to bind with receptors.

The Definitive Guide To Terpenes And Cannabis Aromatherapy
Photo by Kelly Sikkema via Unsplash

It is also important to remember some examples of the entourage effect when cannabinoid is combined. But most cannabis strains that are selectively bred are made to optimize THC and CBD content. So very little is known about the other cannabinoid (there are more than 118 cannabinoids). Which means there are much more potentials for the study of cannabinoid and terpenes if research continues on a large scale.

Bottom line 

One of the most striking things about the entourage effect is that it reinforces the idea that cannabis has a lot of potential. In the future, and as we learn more about the cannabis plant, we will know if it provides additional and impressive benefits for users.

We have discovered the value of CBD and THC separately, but now the world is eager to know, “How much more is there to discover with a combination of CBD and THC?”  The question will hopefully drive the extent of future research and test trials that will boost the positive impact of the entourage effect.

People want more and it is evident with the enormous amount of interest vested in cannabis.

Source: https://thefreshtoast.com/cannabis/cannabis-entourage-effect-fact-or-fiction/

Continue Reading
Advertisement
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

Business

Alleged Crores Pharma Scam Mastermind Arrested from Surat

Published

on

By

After evading law enforcement for nearly 13 years, an accused linked to a large-scale pharmaceutical fraud case has been arrested by Delhi Police from Surat, Gujarat. The suspect is alleged to have orchestrated a series of financial scams involving fake identities, forged documents, and dishonoured cheques used to procure high-value pharmaceutical raw materials.

Authorities say the accused, identified as Himmat Singh Lodha, is believed to have defrauded multiple pharmaceutical companies in Delhi of goods worth approximately ₹98 lakh before disappearing and remaining underground for years.

Fake Business Deals and Dishonoured Cheques Used in Fraud

Investigators claim the accused posed as a legitimate pharmaceutical trader and placed bulk orders for expensive drug ingredients, offering post-dated cheques as payment security.

In one documented case from 2013, he allegedly obtained around 550 kilograms of Gliclazide, a diabetes-related pharmaceutical ingredient, valued at over ₹26 lakh. When suppliers attempted to encash the cheques, they were reportedly returned with the remark “account closed.”

Following the transaction, the accused allegedly vacated his office and rented residence and disappeared without settling payments. He was later declared a proclaimed offender in 2016 after repeatedly failing to appear before court proceedings. Authorities had also issued a reward for information leading to his arrest.

Multiple Identities and Repeated Fraud Pattern

Police investigations further link the accused to another cheating case dating back to 2012, where he allegedly used a fake identity, “Kailash Jain,” to obtain a large consignment of Ambroxol HCL, a pharmaceutical compound used in cough medications. The value of that consignment was estimated at around ₹72 lakh.

Officials believe the accused followed a consistent modus operandi—posing as a credible businessman, securing high-value goods on deferred payment terms, and then disappearing after delivery while shutting down business operations.

Investigators suspect that forged business records, fake company credentials, and fabricated financial histories were used to build trust with suppliers and gain access to expensive raw materials.

Multi-State Surveillance Leads to Arrest in Surat

A special Crime Branch team tracked the accused through coordinated surveillance efforts across multiple cities, including Mumbai, Ahmedabad, and Surat. After nearly a month of technical monitoring and intelligence gathering, officials located and arrested him from a residential area in Surat.

Authorities also revealed that the accused had been involved in property-related activities while staying under the radar to avoid detection.

Growing Threat of Corporate Identity Fraud

The case highlights a rising trend of organised financial fraud targeting industries that rely heavily on trust-based transactions and deferred payments. Experts note that criminals increasingly exploit gaps in corporate verification systems by using fake GST registrations, temporary offices, and forged documentation to appear legitimate.

Cybercrime and financial fraud specialists warn that such schemes are becoming more complex with the widespread availability of digital business tools, making it easier to create convincing but fraudulent corporate identities.

Experts Urge Stronger Due Diligence in High-Value Transactions

Experts, including former IPS officer and cybercrime specialist Prof. Triveni Singh, emphasize the need for stricter verification procedures in commercial dealings. He noted that relying solely on paperwork or digital business profiles can expose companies to significant financial risk.

Authorities and industry experts recommend physical verification of business operations, bank account validation, and detailed background checks before engaging in high-value or deferred-payment transactions—particularly in sectors like pharmaceuticals, where single consignments can involve transactions worth crores.

Continue Reading

Business

EU Pressure Builds on Google as Regulators Face Calls for Massive Fine Over Search Practices

Published

on

By

A growing coalition of European industry groups is intensifying pressure on regulators to take decisive action against Google over allegations of unfair search practices that could reshape competition rules across the region’s digital economy.

Investigation Under Digital Markets Act Gains Momentum

The case is being examined by the European Commission under the European Union’s landmark Digital Markets Act (DMA), introduced to curb the dominance of major technology platforms and ensure fair competition.

Launched in March 2024, the investigation focuses on whether Google has been prioritising its own services in search results, potentially disadvantaging rival businesses that rely on online visibility to reach customers.

Industry Groups Demand Swift Action

Several prominent European organizations have jointly urged regulators to conclude the probe without further delay. They argue that prolonged investigations allow alleged anti-competitive practices to continue, putting European companies—especially startups—at a disadvantage.

Signatories include the European Publishers Council, the European Magazine Media Association, the European Tech Alliance, and EU Travel Tech.

In a joint statement, these groups warned that delays in enforcement are affecting innovation, profitability, and growth prospects for regional businesses competing in digital markets.

Google Denies Allegations

Google has rejected claims of bias, stating that its search algorithms are designed to deliver the most relevant and useful results to users. The company has also proposed adjustments to address regulatory concerns.

However, critics argue that these changes are insufficient and fail to address the core issue of market dominance.

Potential Billion-Euro Penalties

If found in violation of the DMA, Google could face significant financial penalties. Under EU rules, fines can reach a substantial percentage of a company’s global turnover, potentially amounting to billions of euros.

Regulators may also impose corrective measures requiring changes to business practices, which could have long-term implications for how digital platforms operate in Europe.

Wider Implications for Big Tech

The case highlights ongoing tensions between European regulators and major U.S. technology firms. In recent years, the EU has taken a more aggressive stance in enforcing competition laws, aiming to create a level playing field for local businesses.

A final ruling against Google could set a major precedent, influencing future enforcement actions and shaping the regulatory landscape for global tech companies operating within Europe.

As scrutiny intensifies, the outcome of the investigation is expected to play a critical role in defining the future of digital competition across the European Union.

Continue Reading

AI & Technology

Amazon Faces Potential Criminal Trial in Italy Over €1.2 Billion Tax Evasion Allegations

Published

on

By

Milan: U.S. tech giant Amazon is facing the prospect of a major legal showdown in Italy, after prosecutors in Milan formally requested a court to move forward with criminal proceedings over alleged tax evasion totaling approximately ₹12,500 crore (€1.2 billion).

The case targets Amazon’s European division along with four senior executives, marking one of the most significant tax-related investigations involving a global e-commerce platform in Europe.

Trial Push Despite Multi-Million Euro Settlement

The move comes even after Amazon reached a financial settlement with Italian tax authorities in December, agreeing to pay around ₹5,500 crore (€527 million), including interest, to resolve part of the dispute.

Typically, such settlements lead to the closure of criminal investigations. However, Milan prosecutors have opted to proceed, signaling a tougher stance on alleged corporate tax violations.

A preliminary hearing is expected in the coming months, where a judge will decide whether to formally indict the company and its executives or dismiss the case.

Allegations of VAT Evasion Through Marketplace Sellers

At the center of the investigation are claims that Amazon’s platform enabled non-European Union sellers to avoid paying value-added tax (VAT) on goods sold to Italian consumers between 2019 and 2021.

Prosecutors allege that the company’s marketplace structure allowed thousands of foreign vendors—many reportedly based in China—to operate without fully disclosing their identities or tax obligations. This, authorities argue, led to substantial VAT losses for the Italian government.

Under Italian law, online platforms facilitating sales can be held partially liable if third-party sellers fail to comply with tax requirements, a key point in the prosecution’s case.

Italian Government Named as Affected Party

In their filing, prosecutors identified Italy’s Economy Ministry as the injured party, citing significant financial damage resulting from the alleged tax evasion.

Legal experts say the outcome of the case could have wide-ranging implications across the European Union, where VAT systems are harmonized and similar compliance rules apply to digital marketplaces.

Multiple Investigations Add to Pressure

The VAT probe is just one of several legal challenges facing Amazon in Italy. The European Public Prosecutor’s Office is reportedly examining additional tax-related issues covering more recent years.

Meanwhile, Milan authorities are pursuing separate investigations into alleged customs fraud linked to imports from China and whether Amazon maintained an undeclared “permanent establishment” in Italy—potentially exposing it to higher tax liabilities.

In a separate regulatory action, Italy’s data protection authority recently ordered an Amazon unit to stop using personal data from over 1,800 employees at a warehouse near Rome.

Amazon Denies Allegations

Amazon has consistently denied wrongdoing and indicated it will strongly contest the allegations in court if the case proceeds. The company has also warned that prolonged legal uncertainty could impact investor confidence and Italy’s appeal as a destination for international business.

Broader Impact on Europe’s Digital Economy

If the case moves to trial, it could become a landmark moment for the regulation of global e-commerce platforms in Europe. Governments across the region are increasingly scrutinizing how digital marketplaces handle tax compliance, especially in cross-border transactions.

With online retail continuing to expand, regulators are under mounting pressure to ensure that multinational platforms and third-party sellers adhere to the same tax rules as traditional businesses.

Continue Reading

Trending

Copyright © 2022 420 Reports Marijuana News & Information Website | Reefer News | Cannabis News