Business
Data Suggests The Perfect CBD To THC Ratio
When the two are combined in varying ratios, they enhance each other’s beneficial properties synergistically. Here’s what researchers believe to be the best ratio for therapeutic effects.
Researchers from the University of Colorado’s Anschutz Medical Campus analyzed the impact of cannabis flowers with almost equal ratios of THC and CBD, and its effects on subjects. The data suggests the perfect CBD to THC ratio
The study, published in the journal Addiction Biology, examined subjects who were tasked to smoke cannabis flower with various ratios, which were randomly assigned. These included 24% THC and 1% CBD, 23% CBD and 1% THC, as well as flowers that had almost equal ratios of each, 10% THC and 9% CBD. After an hour, the researchers measured their effects.

They found that the patients who smoked the THC dominant cannabis and those who smoked nearly equal ratios and those who smoked the flowers with almost equal ratios experienced similar positive benefits. The difference was that the participants who consumed samples with nearly equal ratios reported less negative side effects including paranoia and anxiety.
“This is one of the first studies to examine the differential effects of various THC and CBD ratios using cannabis flower chemovars that are widely available in state-regulated markets. The present findings suggest that CBD may be associated with an overall reduction of THC exposure and may mitigate the negative psychotomimetic effects of THC without diminishing the effects of THC that individuals report liking,” they write.
“The results of the present study suggest that participants using the THC+CBD chemovar had significantly lower plasma THC levels and reported less paranoia and anxiety as compared to participants using the THC dominant chemovar. Importantly, despite these differences, participants in both the THC+CBD and THC conditions reported similar positive subjective effects… The harm reduction implication of these findings is that cannabis chemovars containing CBD may result in less overall exposure to THC and subsequently less potential for harm, particularly with respect to the psychotomimetic effects of THC,” they concluded.
Why Ratio Matters
CBD and THC are the two primary cannabinoids in the cannabis plant. They each have their own properties; THC is the psychoactive compound that is responsible for making you feel high. The more THC a flower or product contains, the higher you will feel. But aside from just getting you high, THC is widely used for its medicinal properties such as its ability to induce appetite, treat insomnia, stop nausea, and provide relief from pain. However, the right dose is essential because too much THC can make people feel paranoid and anxious. On the other hand, CBD is non-psychoactive and is used for relaxation, insomnia, anxiety, pain, and much more.
When the two are combined in varying ratios, they enhance each other’s beneficial properties synergistically in what is known as the “entourage effect”. Aside from that, all of us have a different biological makeup which is why how you react to CBD may be different from how your friend reacts to CBD, even if you both took exactly the same dose.
It has been recognized by scientists that the ideal dose for most people who want to achieve the most therapeutic benefits is an equal ratio of each, or 1:1 THC CBD. This ratio can help you stay productive without feeling too high since CBD counteracts the highs of THC, while also offering a wide range of health benefits including pain management, anxiety reduction, and better sleep among others.
Common Ratios
When shopping around for cannabis products, those that use a combination of both cannabinoids present various ratios. Here are the most common ratios:
0:1 CBD THC: With no CBD in the product, you will be able to feel the highs of THC which many find to be uplifting and euphoric, while reducing stress. If you are one of those people who are sensitive to THC or have a low tolerance, you may be prone to anxiety and paranoia. However, many people prefer it because it provides relief from pain and inflammation while improving energy and mood.

1:0 CBD THC: A product that has no THC will not make you feel any kind of high. People who enjoy the relaxation brought about by CBD will appreciate these types of products as they can mildly sedate while still improving your mood and helping to reduce anxiety and panic attacks.
1:1 CBD THC: For people who aren’t familiar with CBD and THC, this is the recommended ratio to start with. You will be able to experience the best of both worlds, but also the presence of CBD will negate getting too high from the THC. In addition, you will be able to stay functional and productive.
1:9 or more: These are usually high-THC products, which means that you will likely experience the characteristics that are typically associated with THC. These may be beneficial for people who are suffering from severe pain, nausea, migraines, lack of appetite due to chemotherapy or radiation, and more. Just keep in mind that it also means you will get a high.
Aside from these, you will also encounter other ratios in the market such as 2:1, 3:1, or 4:1 as well as 25: 1 and others. If you aren’t sure where to start, remember that the more CBD it contains, the less THC psychoactivity you will experience. If you don’t want to get high, always opt for a product that has a higher CBD content or an equal ratio.
Talk to a budtender at your nearest dispensary to learn more about recommendations based on your personal needs. These ratios are available in many cannabis products from oils to tinctures, edibles, and so much more.
Source: https://thefreshtoast.com/cannabis/the-perfect-cbd-to-thc-ratio-this-is-what-a-new-study-suggests/
Business
A Tipping Point for Cannabis: President Trump Champions CBD & Cannabis Science on Truth Social
When the President of the United States shares a video about the life changing potential of hemp derived CBD on his personal social media platform, it is more than news, it is a cultural shift.
For decades our government lied to us about cannabis. It demonized the plant, waged war on its users, and filled prisons while allowing pharmaceutical companies to flood the nation with addictive and deadly drugs. For over a century we have been fighting uphill, not just for legalization, but for truth, for science, and for the right to heal ourselves naturally.
Now in 2025, the most powerful political figure on Earth is using his own voice and platform to talk about the endocannabinoid system and the science backed benefits of CBD. That is monumental. It is validation for everyone who has fought, been arrested, been silenced, and been dismissed for telling this truth. The President’s video post is already being described as a pivotal moment in cannabis history, and President Trump CBD Cannabis Science Truth Social is trending across platforms as advocates celebrate the breakthrough.
The Science Behind the Endocannabinoid System
The video begins by introducing something most people, including many doctors, still know little about, the endocannabinoid system. Discovered in the 1990s, the ECS is a network of receptors and signaling molecules that works as the body’s master regulator, coordinating communication between major systems like the nervous, immune, cardiovascular, and digestive systems.
The roots of this discovery go back much further. CBD was first isolated in 1940 by American chemist Roger Adams, but it was Dr. Raphael Mechoulam, an Israeli organic chemist, who fully elucidated the chemical structure of CBD and identified its stereochemistry in the 1960s. His pioneering work not only opened the door to modern cannabinoid science but also earned him the title “Godfather of Cannabis Research.” It was this foundation that led to the identification of the endocannabinoid system itself decades later, revealing how cannabinoids interact with our physiology on a fundamental level.
The ECS is now widely recognized as a vital part of human biology, with extensive research supported by the National Institutes of Health. When functioning properly, the ECS acts like the conductor of an orchestra, ensuring every section plays in harmony. As we age, the system weakens. That imbalance is linked to inflammation, chronic pain, cognitive decline, sleep problems, and many other conditions associated with aging.
Mainstream medicine often addresses these issues with pharmaceutical band aids, dangerous and addictive drugs that treat symptoms rather than root causes. Lifestyle changes such as diet and exercise help, but they only partially support the ECS and do so slowly over time.
Hemp Derived CBD: A Game Changer for Aging
Here is where the science gets exciting. As the video explains, the ECS can be restored much more quickly with hemp derived CBD. Strengthening this system naturally helps the body regain balance, reducing pain, improving sleep, lowering stress, slowing disease progression, and even extending healthy lifespan.
It is not theoretical. One in five seniors is already using CBD to manage pain, arthritis, cancer symptoms, sleep disorders, Alzheimer’s, and more. Despite decades of research and acknowledgment from institutions like the National Institutes of Health, most physicians receive no training on the ECS. There are still no FDA standards for CBD products on the market. If that were the case for any other class of medicine, it would be considered malpractice.
The World Health Organization has confirmed CBD’s excellent safety profile and non addictive nature in its critical review report. The result is that millions of older Americans are suffering unnecessarily when a safe and natural solution exists.
Hemp derived CBD is a powerful first step in restoring balance to the endocannabinoid system, but it is only part of the picture. Research shows that full spectrum cannabis extracts, which include a broader range of cannabinoids and terpenes, can work even more effectively. Complete concentrated cannabis oil, containing the full spectrum of natural endocannabinoids, may deliver the most profound results for certain patients. Expanding access to these therapies will be essential if we want to unlock the full healing potential of this plant.
The Economic and Social Impact
The video cites a powerful figure. A PricewaterhouseCoopers analysis estimates that fully integrating cannabis into the healthcare system could save the United States nearly 64 billion dollars annually. These savings reflect reduced pharmaceutical dependency, fewer hospitalizations, improved chronic disease outcomes, and enhanced quality of life for aging Americans. You can read more about PwC’s research on healthcare innovation here.
It is a financial argument, but it is also a moral one. Why should our elders endure pain, anxiety, and cognitive decline when nature has given us tools to help them live longer, happier, and healthier lives?
A Call to Action: Finish What the Farm Bill Started
The message concludes by crediting the 2018 Farm Bill, championed by President Trump, for legalizing hemp and laying the groundwork for today’s CBD market. The Farm Bill was just the first step.
Now the call is for bold next moves.
- Educate doctors about the endocannabinoid system
- Include CBD under Medicare coverage
- Provide clear federal standards for CBD quality and dosing
These steps would constitute the most significant senior health reform in modern history, one that would transform aging and cement a powerful legacy for any administration that makes it happen.
What This Means for Future Cannabis Medicine
For those of us who have been in the cannabis community for decades, this is not just another news story. It is a signal that our movement is winning. A conversation that was once criminalized and censored is now being amplified by the President of the United States on his own platform.
It means the science is undeniable. It means the truth can no longer be buried. It means the wall of prohibition is cracking, not just legally, but culturally, scientifically, and politically.
It also means that everything we have been fighting for at 420 Magazine since 1993, education, access, healing, and justice, is finally moving full steam ahead. The President Trump CBD Cannabis Science Truth Social moment is proof that science and policy are finally converging.
Business
New Mexico cannabis operator fined, loses license for alleged BioTrack fraud
New Mexico regulators fined a cannabis operator nearly $300,000 and revoked its license after the company allegedly created fake reports in the state’s traceability software.
The New Mexico Cannabis Control Division (CCD) accused marijuana manufacturer and retailer Golden Roots of 11 violations, according to Albuquerque Business First.
Golden Roots operates the The Cannabis Revolution Dispensary.
The majority of the violations are related to the Albuquerque company’s improper use of BioTrack, which has been New Mexico’s track-and-trace vendor since 2015.
The CCD alleges Golden Roots reported marijuana production only two months after it had received its vertically integrated license, according to Albuquerque Business First.
Because cannabis takes longer than two months to be cultivated, the CCD was suspicious of the report.
After inspecting the company’s premises, the CCD alleged Golden Roots reported cultivation, transportation and sales in BioTrack but wasn’t able to provide officers who inspected the site evidence that the operator was cultivating cannabis.
In April, the CCD revoked Golden Roots’ license and issued a $10,000 fine, according to the news outlet.
The company requested a hearing, which the regulator scheduled for Sept. 1.
At the hearing, the CCD testified that the company’s dried-cannabis weights in BioTrack were suspicious because they didn’t seem to accurately reflect how much weight marijuana loses as it dries.
Company employees also poorly accounted for why they were making adjustments in the system of up to 24 pounds of cannabis, making comments such as “bad” or “mistake” in the software, Albuquerque Business First reported.
Golden Roots was fined $298,972.05 – the amount regulators allege the company made selling products that weren’t properly accounted for in BioTrack.
The CCD has been cracking down on cannabis operators accused of selling products procured from out-of-state or not grown legally:
- Regulators alleged in August that Albuquerque dispensary Sawmill Sweet Leaf sold out-of-state products and didn’t have a license for extraction.
- Paradise Exotics Distro lost its license in July after regulators alleged the company sold products made in California.
Golden Roots was the first alleged rulebreaker in New Mexico to be asked to pay a large fine.
Source: https://mjbizdaily.com/new-mexico-cannabis-operator-fined-loses-license-for-alleged-biotrack-fraud/
Business
Marijuana companies suing US attorney general in federal prohibition challenge
Four marijuana companies, including a multistate operator, have filed a lawsuit against U.S. Attorney General Merrick Garland in which they allege the federal MJ prohibition under the Controlled Substances Act is no longer constitutional.
According to the complaint, filed Thursday in U.S. District Court in Massachusetts, retailer Canna Provisions, Treevit delivery service CEO Gyasi Sellers, cultivator Wiseacre Farm and MSO Verano Holdings Corp. are all harmed by “the federal government’s unconstitutional ban on cultivating, manufacturing, distributing, or possessing intrastate marijuana.”
Verano is headquartered in Chicago but has operations in Massachusetts; the other three operators are based in Massachusetts.
The lawsuit seeks a ruling that the “Controlled Substances Act is unconstitutional as applied to the intrastate cultivation, manufacture, possession, and distribution of marijuana pursuant to state law.”
The companies want the case to go before the U.S. Supreme Court.
They hired prominent law firm Boies Schiller Flexner to represent them.
The New York-based firm’s principal is David Boies, whose former clients include Microsoft, former presidential candidate Al Gore and Elizabeth Holmes’ disgraced startup Theranos.
Similar challenges to the federal Controlled Substances Act (CSA) have failed.
One such challenge led to a landmark Supreme Court decision in 2005.
In Gonzalez vs. Raich, the highest court in the United States ruled in a 6-3 decision that the commerce clause of the U.S. Constitution gave Congress the power to outlaw marijuana federally, even though state laws allow the cultivation and sale of cannabis.
In the 18 years since that ruling, 23 states and the District of Columbia have legalized adult-use marijuana and the federal government has allowed a multibillion-dollar cannabis industry to thrive.
Since both Congress and the U.S. Department of Justice, currently headed by Garland, have declined to intervene in state-licensed marijuana markets, the key facts that led to the Supreme Court’s 2005 ruling “no longer apply,” Boies said in a statement Thursday.
“The Supreme Court has since made clear that the federal government lacks the authority to regulate purely intrastate commerce,” Boies said.
“Moreover, the facts on which those precedents are based are no longer true.”
Verano President Darren Weiss said in a statement the company is “prepared to bring this case all the way to the Supreme Court in order to align federal law with how Congress has acted for years.”
While the Biden administration’s push to reschedule marijuana would help solve marijuana operators’ federal tax woes, neither rescheduling nor modest Congressional reforms such as the SAFER Banking Act “solve the fundamental issue,” Weiss added.
“The application of the CSA to lawful state-run cannabis business is an unconstitutional overreach on state sovereignty that has led to decades of harm, failed businesses, lost jobs, and unsafe working conditions.”
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