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Take a Pill to Quit Smoking Weed? – Cannabis Use Disorder Pill Starts Clinical Trials

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What is Cannabis Use Disorder and do you need a pill to help you get off weed?

pill to quit weed

While many cannabis producers and marketers might not want to openly declare it, excessive use of cannabis is detrimental to health. Cannabis Use Disorder has been the name used to describe this condition and has seen been as a matter for the pharmaceutical industry to give an answer to. It would seem that Segal Trials has done just that as its new drug is set to commence clinical trials for cannabis use disorder.  Read on as we explore all that there is to know about the new drug that is set to begin its clinical trials.

Cannabis Use Disorder

Cannabis Use Disorder is a condition where severe use of cannabis leads to dependency in the user and promotes deleterious effects. Common symptoms of cannabis use disorder include depression, restlessness, anxiety, irritability, anxiety, and dysphoria. It is also known as cannabis addiction or marijuana addiction. The point of tagging a condition as cannabis use disorder is when the user doesn’t cease its use despite apparent social and health problems being linked to its use.

The prolonged use of cannabis which causes the user to develop tolerance to the effects of THC is one of the mechanisms causing cannabis use disorder. This causes dependency in some chronic cannabis users and any attempt to cease causes withdrawal symptoms. Another factor that can promote the early onset of this condition in some individuals is the drastic increase in the potency of cannabis taken. A change in the mode of delivery can also hasten the development of dependency and eventually cannabis use disorder.

Is a pharmaceutical solution on the way?

The issues associated with a dependency that comes with cannabis use disorder are there for all to see but a pharmaceutical solution is already on the horizon. Segal Trials, a clinical research network based in South Florida recently announced that it will soon commence Phase 2B study for a new drug for cannabis use disorder. The drug designated as AEF0117-202 as disclosed in a press release on October 5 is being created by Aelis Farma. The Phase 2 study that is about to commence is a random, double-blind, placebo-controlled study. The study will consist of 4-arms, a parallel group and a multicenter towards determining its efficacy.

The new drug is being classified under a new class of drugs called sCB1-SSi. It will be the first of such drugs chosen as a clinical candidate towards the treatment of cannabis use disorder. The drug is expected to react to the same endocannabinoid receptors as THC in the body. This effect is expected to create a stop in the dependency and halt the progression of deleterious symptoms that might come with withdrawal.

More on the clinical trials

For the purpose of the trials to be carried out to determine the efficacy of the drug, a criterion has been set to classify how much cannabis is too much. People with cannabis use disorder are defined as those who use cannabis five times per week or more. Such selected individuals are to be chosen as study participants. A group of these participants are to be administered the trial drug orally while another group will be given a placebo.

Three different doses of the trial drug (0.1mg, 0.3mg, and 1.0mg) are to be given to the study participants in capsules. Results from the test will justify the hypothesis that since AEF0117 acts across similar receptors as THC, it can alter some of the effects of cannabis. The Medical Director and Chief Scientific Officer at Segal Trials, Rishi Kakar believes the study will help people desperate to end their reliance on cannabis.

The cannabis withdrawal symptoms being used in the study include cravings, restlessness, decreased appetite, irritability, and mood and sleep difficulties. A recent study by the Center for Disease Control and Prevention shows that 3 of 10 cannabis users suffer from cannabis use disorder. Another study also shows that there is a 10 percent chance that people who use cannabis will become addicted. This shows the importance of the work being done by Segal Trials on the development of a pharmaceutical drug for cannabis use disorder.

The trial for the new drug to be done by Segal Trials is said to be done at the Center for Psychedelic and Cannabis Research. The centre was specifically built for such structured trials to promote patient comfort and patient safety while conducting the trials. The team has also worked on psychedelics to conduct a clinical trial on the efficacy of LSD D-tartrate for treating general anxiety disorder. This serves as a foundational basis for which the group seeks to establish this new drug as a solution to cannabis use disorder.

Factors promoting the rise in cannabis use disorder

One of the major factors that have been identified for the increase in cannabis use disorder is the rise in dabbing. The presence of new and modified modes of delivery of cannabis has resulted in an increase in the potency of THC as more concentrates are being developed. This has resulted in the development of cannabis products with high potency over the last twenty years.

The absence of an approved drug for cannabis use disorder has also increased the incidence of the condition. The lack of a proper definition of the condition for a long time resulted in a lack of clinical research on it for quite some time. This in turn created an absence of considerable literature that is needed to facilitate the development of the pharmaceutical drug.

Summary

The development of the new drug and the commencement of its clinical trials are definitely comforting news for many. The menace of cannabis use disorder is one that many have continued to shy away from for quite some time. However, if the results of these clinical trials come back successful then we can be looking towards the development of a new era. An era where cannabis dependency and withdrawal symptoms are a thing that can be corrected by the work of a pharmaceutical pill.

Source: https://cannabis.net/blog/medical/take-a-pill-to-quit-smoking-weed-cannabis-use-disorder-pill-starts-clinical-trials

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New Mexico cannabis operator fined, loses license for alleged BioTrack fraud

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New Mexico regulators fined a cannabis operator nearly $300,000 and revoked its license after the company allegedly created fake reports in the state’s traceability software.

The New Mexico Cannabis Control Division (CCD) accused marijuana manufacturer and retailer Golden Roots of 11 violations, according to Albuquerque Business First.

Golden Roots operates the The Cannabis Revolution Dispensary.

The majority of the violations are related to the Albuquerque company’s improper use of BioTrack, which has been New Mexico’s track-and-trace vendor since 2015.

The CCD alleges Golden Roots reported marijuana production only two months after it had received its vertically integrated license, according to Albuquerque Business First.

Because cannabis takes longer than two months to be cultivated, the CCD was suspicious of the report.

After inspecting the company’s premises, the CCD alleged Golden Roots reported cultivation, transportation and sales in BioTrack but wasn’t able to provide officers who inspected the site evidence that the operator was cultivating cannabis.

In April, the CCD revoked Golden Roots’ license and issued a $10,000 fine, according to the news outlet.

The company requested a hearing, which the regulator scheduled for Sept. 1.

At the hearing, the CCD testified that the company’s dried-cannabis weights in BioTrack were suspicious because they didn’t seem to accurately reflect how much weight marijuana loses as it dries.

Company employees also poorly accounted for why they were making adjustments in the system of up to 24 pounds of cannabis, making comments such as “bad” or “mistake” in the software, Albuquerque Business First reported.

Golden Roots was fined $298,972.05 – the amount regulators allege the company made selling products that weren’t properly accounted for in BioTrack.

The CCD has been cracking down on cannabis operators accused of selling products procured from out-of-state or not grown legally:

Golden Roots was the first alleged rulebreaker in New Mexico to be asked to pay a large fine.

Source: https://mjbizdaily.com/new-mexico-cannabis-operator-fined-loses-license-for-alleged-biotrack-fraud/

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Marijuana companies suing US attorney general in federal prohibition challenge

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Four marijuana companies, including a multistate operator, have filed a lawsuit against U.S. Attorney General Merrick Garland in which they allege the federal MJ prohibition under the Controlled Substances Act is no longer constitutional.

According to the complaint, filed Thursday in U.S. District Court in Massachusetts, retailer Canna Provisions, Treevit delivery service CEO Gyasi Sellers, cultivator Wiseacre Farm and MSO Verano Holdings Corp. are all harmed by “the federal government’s unconstitutional ban on cultivating, manufacturing, distributing, or possessing intrastate marijuana.”

Verano is headquartered in Chicago but has operations in Massachusetts; the other three operators are based in Massachusetts.

The lawsuit seeks a ruling that the “Controlled Substances Act is unconstitutional as applied to the intrastate cultivation, manufacture, possession, and distribution of marijuana pursuant to state law.”

The companies want the case to go before the U.S. Supreme Court.

They hired prominent law firm Boies Schiller Flexner to represent them.

The New York-based firm’s principal is David Boies, whose former clients include Microsoft, former presidential candidate Al Gore and Elizabeth Holmes’ disgraced startup Theranos.

Similar challenges to the federal Controlled Substances Act (CSA) have failed.

One such challenge led to a landmark Supreme Court decision in 2005.

In Gonzalez vs. Raich, the highest court in the United States ruled in a 6-3 decision that the commerce clause of the U.S. Constitution gave Congress the power to outlaw marijuana federally, even though state laws allow the cultivation and sale of cannabis.

In the 18 years since that ruling, 23 states and the District of Columbia have legalized adult-use marijuana and the federal government has allowed a multibillion-dollar cannabis industry to thrive.

Since both Congress and the U.S. Department of Justice, currently headed by Garland, have declined to intervene in state-licensed marijuana markets, the key facts that led to the Supreme Court’s 2005 ruling “no longer apply,” Boies said in a statement Thursday.

“The Supreme Court has since made clear that the federal government lacks the authority to regulate purely intrastate commerce,” Boies said.

“Moreover, the facts on which those precedents are based are no longer true.”

Verano President Darren Weiss said in a statement the company is “prepared to bring this case all the way to the Supreme Court in order to align federal law with how Congress has acted for years.”

While the Biden administration’s push to reschedule marijuana would help solve marijuana operators’ federal tax woes, neither rescheduling nor modest Congressional reforms such as the SAFER Banking Act “solve the fundamental issue,” Weiss added.

“The application of the CSA to lawful state-run cannabis business is an unconstitutional overreach on state sovereignty that has led to decades of harm, failed businesses, lost jobs, and unsafe working conditions.”

Source: https://mjbizdaily.com/marijuana-companies-suing-us-attorney-general-to-overturn-federal-prohibition/

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Alabama to make another attempt Dec. 1 to award medical cannabis licenses

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Alabama regulators are targeting Dec. 1 to award the first batch of medical cannabis business licenses after the agency’s first two attempts were scrapped because of scoring errors and litigation.

The first licenses will be awarded to individual cultivators, delivery providers, processors, dispensaries and state testing labs, according to the Alabama Medical Cannabis Commission (AMCC).

Then, on Dec. 12, the AMCC will award licenses for vertically integrated operations, a designation set primarily for multistate operators.

Licenses are expected to be handed out 28 days after they have been awarded, so MMJ production could begin in early January, according to the Alabama Daily News.

That means MMJ products could be available for patients around early March, an AMCC spokesperson told the media outlet.

Regulators initially awarded 21 business licenses in June, only to void them after applicants alleged inconsistencies with how the applications were scored.

Then, in August, the state awarded 24 different licenses – 19 went to June recipients – only to reverse themselves again and scratch those licenses after spurned applicants filed lawsuits.

A state judge dismissed a lawsuit filed by Chicago-based MSO Verano Holdings Corp., but another lawsuit is pending.

Source: https://mjbizdaily.com/alabama-plans-to-award-medical-cannabis-licenses-dec-1/

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