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Scientists Discover New Cannabis Compounds, But What Exactly Are They?

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Marijuana is the most widely used “illicit” drug in the entire world.

It’s also the most popular, with millions of consumers now using it legally all the world thanks to many countries relaxing its stance following suit after the United States, Canada, and Uruguay. However, from a scientific perspective, we know so little about the compounds in the plant. So far there are 500 known compounds in the plant but only two cannabinoids, tetrahydrocannabinol (THC) and cannabidiol (CBD) have been extensively studied numerous times over. We have been able to identify their therapeutic applications for dozens of afflictions though that’s not to say that they are the only 2 valuable compounds in the plant.

THC is the cannabinoid responsible for its psychoactive properties, and it also has important therapeutic benefits. On the other hand, CBD doesn’t cause a high but it’s widely marketed as a powerful sedative. Both have potent anti-inflammatory properties that help provide relief from pain, spasms, anxiety, depression, trauma, and more.

But over the last few years, scientists have been able to identify even more compounds within the plant that are beneficial for us. There are several other major and minor cannabinoids and terpenes that all have terrific medicinal value in many different ways; in addition, it also contains flavonoids and omega-3 fatty acids.

Let’s look at some of the recent discoveries.

Kynurenine, Kynurenic Acid, and Tryptophan

In March 2022, Italian researchers have identified tryptophan, kynurenine, and kynurenic acid in cannabis for the first time earlier this year. Though these compounds already exist in us humans as well as mammals, kynurenine is a metabolite of tryptophan, which is an amino acid that we can’t produce ourselves. Hence, we need to rely on our food intake to get enough of it.

Through high-resolution mass spectrometry and liquid chromatography, they found that these compounds exist all over the plant though it’s in much larger amount within the leaves. It’s also interesting for the researchers that kynurenic acid is highly concentrated in cannabis compared to other plants, since it has also been found in some vegetables including potato, pumpkin, and broccoli – as well as other herbs and spices.

According to the researchers, 95% of tryptophan in the human body is metabolized into kynurenine, though some of it further degrades to kynurenic acid. The latter is piquing the interest of researchers because of its neuroprotective, anti-inflammatory, and anti-oxidative benefits especially for the heart and the brain. In addition, tryptophan metabolites are known for helping to regulate lipids and mitigating obesity.

“Considering the important role played by kynurenic acid in animals and humans, its accumulation in the leaves opens a new branch of the cannabis chemistry that makes this plant even more attractive than it already is,” they concluded.

THCP and CBDP

In 2019, Italian researchers also accidentally discovered two cannabinoids namely THCP and CBDP while studying an industrial strain of hemp. The same team discovered THCB and CBDB in the year before, but being able to identify THCP was extremely significant because it may help us better understand why some strains with low THC levels are still extremely powerful in both their high and their medicinal value.

Using mouse models, they discovered that the binding mechanism of THCP on the animals’ CB1 receptors resulted in similar effects as THC even when they only used half a dose.  They found that THCP was 33 times more active on the CB1 receptor compared to THC, while it was also 5-10 times more active on the CB2 receptor. In addition, they found that THCP is easier to dissolve in fats.

This is why cannabis strains that contain more THCP are more powerful compared to those that only contain THC.

On the other hand, they also discovered CBDP, also known as CBD-C7 or CBD-heptyl. Unfortunately, we still know significantly less about CBDP compared to THCP but researchers have deprioritized studying it simply because it had less efficacy binding to CB1 and CB2 receptors.

Though there’s still a lot we don’t know about THCP, the Italian researchers did discover that it may have potential for pain relief, hypomobility, and helping reduce temperature within the rectum.

“In our opinion, this compound should be included in the list of the main phytocannabinoids to be determined for a correct evaluation of the pharmacological effect of the cannabis extracts administered to patients,” said the researchers. “In fact, we believe that the discovery of an extremely potent THC-like phytocannabinoid may shed light on several pharmacological effects not ascribable solely to THC,” they conclude.

For those interested to explore what THCP feels like, you may be interested to know that some cannabis brands already sell THCP products in the market.

Conclusion

Even if marijuana is legal in one form or another in a majority of US states, researching it is a completely different beast. Cannabis research in the United States is notoriously difficult, which is why many of these new, recent discoveries on the plant’s compounds are done by researchers abroad.

Currently, cannabis is still a federally illegal substance and it’s still listed as a Schedule 1 drug at the time of writing. This hasn’t stopped researches from both near and far from studying what they can about the plant, and it looks like we can still expect exciting new discoveries in the upcoming years. Learning about the plant should be something that supporters as well as opponents of marijuana legalization should welcome because unbiased research will only help us move forward and make more educated decisions – both for patients and doctors.

Source: https://cannabis.net/blog/medical/scientists-discover-new-cannabis-compounds-but-what-exactly-are-they

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Business

Pot Odor Does Not Justify Probable Cause for Vehicle Searches, Minnesota Court Affirms

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The Minnesota Supreme Court affirmed that cannabis odor does not constitute probable cause to search a vehicle.

If Minnesota police search a vehicle solely based upon the smell of pot, they can’t justify searching a vehicle, even if there is evidence found of other alleged crimes. Even after appealing a lower court decision to suppress the evidence—twice—the Minnesota Supreme Court agreed, and the dismissal of his charges stands.

In a ruling filed regarding a case the State of Minnesota Court of Appeals on Sept. 13, the Minnesota Supreme Court affirmed that cannabis odor does not constitute probable cause to search a vehicle.

The case has been ongoing for two years. On July 5, 2021, just before 10 p.m., a Litchfield police officer stopped a car for an obscure local law: the light bar mounted on the vehicle’s grill had more auxiliary driving lights than are permitted under Minnesota law. The officer asked the driver, Adam Lloyd Torgerson, for his license and registration. Torgerson, his wife, and his child were present in the vehicle. The officer stated that he smelled pot and asked Torgerson if there was any reason for the odor, which he initially denied. But cops found a lot more than just pot.

A backup officer was called in. The couple denied possessing any pot, but Torgerson admitted to smoking weed in the past. The second officer stated that the weed odor gave them probable cause to search the vehicle and ordered them to exit the vehicle. The first officer searched the vehicle and found a film canister, three pipes, and a small plastic bag in the center console. The plastic bag contained a white powder and the film canister contained meth, which was confirmed in a field test.

Torgenson was charged with possession of meth pipe in the presence of a minor and fifth-degree possession of a controlled substance after the unwarranted search of Torgerson’s vehicle. 

Police Aren’t Allowed to Do That, Multiple Courts Rule

But the search had one major problem—cops weren’t searching for a meth pipe. They only searched his car because they could smell pot, and the meth and paraphernalia were a surprise for everyone. Still, they had no grounds to search the vehicle. The man’s charges were later dismissed after the district court determined the odor of cannabis alone was insufficient basis for probable cause to search the vehicle, regardless of whatever other drug paraphernalia they found. 

The state appealed the case, but the Minnesota Court of Appeals affirmed the district court’s decision. The case was appealed a second time, this time to the Minnesota Supreme Court, which agreed with the lower court’s ruling. 

 “This search was justified only by the odor of marijuana emanating from the vehicle,” the Minnesota Supreme Court decision reads. “Torgerson moved to suppress the evidence found during the search, arguing that the odor of marijuana, alone, is insufficient to create the requisite probable cause to search a vehicle under the automobile exception to the warrant requirement. The district court granted Torgerson’s motion, suppressed the evidence, and dismissed the complaint. The State appealed. The court of appeals affirmed the district court’s suppression order. Because we conclude that the odor of marijuana emanating from a vehicle, alone, is insufficient to create the requisite probable cause to search a vehicle under the automobile exception to the warrant requirement, we affirm.”

It amounts to basic human rights that apply—regardless of whether or not a person is addicted to drugs.

Other States do Precisely the Same Regarding Pot Odor as Probably Cause

An Illinois judge ruled in 2021 that the odor of cannabis is not sufficient grounds for police to search a vehicle without a warrant during a traffic stop.

Daniel J. Dalton, Associate Judge of the 14th Judicial Circuit, issued a ruling in response to a motion to suppress evidence in the case of Vincent Molina, a medical cannabis patient arrested for cannabis possession last year.

In that case, Molina was arrested despite the decriminalization of small amounts of cannabis in Illinois in 2019 with the passage of the Illinois Cannabis Regulation and Tax Act. 

In some states, the issue of probable cause and cannabis was defined through bills.

Last April, the Maryland House of Delegates approved a bill that reduces the penalties for public cannabis consumption and bars police from using the odor of cannabis as the basis for the search of an individual or auto. Under Maryland’s House Bill 1071, law enforcement officers would be prohibited from using the odor of raw or burnt cannabis as probable cause to search a person or vehicle. 

The rulings represent the rights of citizens when they are pulled over by police, even if there are hard drugs involved.

Source: https://hightimes.com/news/pot-odor-does-not-justify-probable-cause-for-vehicle-searches-minnesota-court-affirms/

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Legal Marijuana Handed A Nothing Burger From NY State

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Following the chaos of the recreational weed rollout, the government is trying to figure out next steps. But it seems legal marijuana has been handed a nothing burger from NY state with their last rollout for potential cannabis retailers.. With an estimated $3.5 billion in sales at stake along with tax revenue for the state’s every growing budget, the fumble is costly for a significant number of players.  And it has been a huge loss for the marijuana industry as a whole.

What was quickly seen as an opportunity was pounced on in the city with the most billionaires globally along with endless big and small entrepreneurs, and hustlers. Seeing a huge amount of cash on the table, players acted in a quickly in a way bureaucrats will never understand.

Embracing a Wild West approach, officials decriminalizated and fumbled licensed legalization of sales.  Despite promises and initial outlines where existing medical marijuana dispensaries could switch to recreational and a fair, for government quick liscnese process, the state tossed it all in one stroke. In a vision of equity, officials decided to reserve the first retail licenses for felons and other “justice-involved” individuals.  Lawsuits started, the desired licensees struggled to raise capital and over 1,600 unlicensed retail stores opened in NYC. For the small time players, they have set sidewalk card tables parks, selling roll-ups and handmade marijuana edibles, in full view of the police.

The updated systems was rolled out, but has left people confused, dispirited, and disappointed. The Office of Cannabis Management rolled out the previous Conditional Adult-Use Retail Dispensaries (CAURD) program with high hopes.  Now, regulators voted to allow the state’s medical marijuana operators to apply for adult-use retail licenses.  Multistate operators who have patiently acquired a majority of the state’s 10 registered organization.

“It was more like an orgy of minimalism. While they are getting ready to open the application window on October 4th (notably, originally it wasn’t intended to be a 60-day window, but rolling applications) for most license types (sans on-site consumption and delivery), they refused to address the CAURD program.  Other than to suggest that it remains “a priority”, they have offered only some subtle hints in the guidance to the regulations. These include establishing a priority for retail applications which include secured real estate, which will be given priority after the initial 30-days of the 60-day application window have passed (although they do not define what that means).  And noting that existing licensees may apply for an additional license so long as they comply with the rules of a two-tier system.  The positive news is that these statements can be interpreted as an invitation to current CAURD licensees, many of whom will also meet other Social and Economic Equity (SEE) criteria entitling them to an additional priority.” shares Andrew Cooper, partner at Falcon Rappaport & Berkman LLP, one of the top cannabis law firms.

Unfortunately, there are multiple losers in the state’s unique approach.  One is consumer and medical marijuana patients, including veterans.  The unlicensed dispensaries are making a mint and overcharging customers due to high demand. Small investors and companies, including those who could be a player in the CAURD, will not have the financial to compete with multi-state and large players. And taxpayers will lose out for years to come as revue it lost to unlicensed dispensaries.

The good news, consumers will continue to find products easily over the next few years.  There is even a thriving unlicensed dispensary a few blocks from City Hall.

While New York is awash with billionaires, fashion, food and smarts, common sense seems to be lack for making a good government plan.

Source: https://thefreshtoast.com/cannabis/legal-marijuana-handed-a-nothing-burger-from-ny-state/

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Healthcare

This Activity Helps Those With Depression And Anxiety

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A new study shows that exercise is extremely helpful for people coping with a mental health condition, affecting them more than people who don’t share these struggles.

One of the activities that people first recommend when discussing conditions like depression and anxiety is exercise. The suggestion is so pervasive that it’s almost a cliche by now. Still, evidence shows that exercise is incredibly helpful for your mental health, decreasing muscle tension, promoting the production of serotonin, and more.

A British study suggests that people with depression and anxiety are twice as likely to reap the benefits of exercise when compared to people who don’t suffer from these conditions.

The data was obtained by tracking the exercise patterns of over 50,000 people in their late fifties. About a third of them were affected by health conditions like depression and anxiety. While everyone experienced benefits from moderate amounts of exercise, people who had a mental health condition experienced 22 percent less risk of having a heart attack or a blocked coronary artery. For reference purposes, the majority of candidates only experienced a 17 percent decrease in their odds of suffering from a cardiac condition.

“The effect of physical activity on the brain’s stress response may be particularly relevant in those with stress-related psychiatric conditions. This is not to suggest that exercise is only effective in those with depression or anxiety, but we found that these patients seem to derive a greater cardiovascular benefit from physical activity,” said the lead researcher of the study, Hadil Zureigat.

Anxiety and other forms of stress can result in inflammation, a condition that creates risks for people’s circulatory systems. The effect of exercise targets different risk factors for people with an existing mental health condition, reducing the cortisol in their bodies and increasing cardiovascular health, all the while producing serotonin and boosting their moods.

Introducing a workout routine into your life when you don’t have one isn’t easy, but it’s often suggested to start off slow, taking your time to find an activity you find enjoyable. Just one exercise session can make you feel better, but the more you commit to it, the easier it gets to create a habit. Try working out with friends, outdoors, signing up to sports or classes  whatever keeps you accountable, and returning to your activity.

Source: https://thefreshtoast.com/news/this-activity-helps-those-with-depression-and-anxiety/

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